Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis
Atopic dermatitis is a chronic, inflammatory skin disease. A variety of systemic treatments are available for patients with moderate-to-severe atopic dermatitis. The efficacy, safety and administration profile of these treatments vary, and determining the optimal treatment strategy may require weigh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2024-02-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/24339 |
| _version_ | 1797300942538801152 |
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| author | Mahreen Ameen Raed Alhusayen Henrik Brandi Mette Bøgelund Henrik H. Jensen Signe B. Reitzel Jacob P. Thyssen |
| author_facet | Mahreen Ameen Raed Alhusayen Henrik Brandi Mette Bøgelund Henrik H. Jensen Signe B. Reitzel Jacob P. Thyssen |
| author_sort | Mahreen Ameen |
| collection | DOAJ |
| description | Atopic dermatitis is a chronic, inflammatory skin disease. A variety of systemic treatments are available for patients with moderate-to-severe atopic dermatitis. The efficacy, safety and administration profile of these treatments vary, and determining the optimal treatment strategy may require weighing the benefits and drawbacks of therapies with diverse characteristics. This study used an online discrete choice experiment survey to investigate treatment preferences among adults with atopic dermatitis from Denmark, France, the UK, or Canada. Participants were identified through existing online panels. The survey included questions regarding different treatment attributes, defined based on currently approved treatments for moderate to severe atopic dermatitis. Treatment preferences were measured as the relative importance of different treatment attributes. A total of 713 respondents met the inclusion criteria and completed the survey. The discrete choice experiment identified a significant preference for avoiding the risk of severe adverse events, and for oral pill every day compared with biweekly injections. The time to full effect was not rated as being important. These findings suggest that patients with moderate-to-severe atopic dermatitis prioritize safety as most important, followed by ease of administration in their treatment preferences, while time to full effect and monitoring requirements were the least important attributes.
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| first_indexed | 2024-03-07T23:15:20Z |
| format | Article |
| id | doaj.art-b02451ed21434f8ebd53d211765d90df |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-07T23:15:20Z |
| publishDate | 2024-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-b02451ed21434f8ebd53d211765d90df2024-02-21T13:56:43ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572024-02-0110410.2340/actadv.v104.24339Patient Preferences in the Treatment of Moderate-to-severe Atopic DermatitisMahreen Ameen0Raed Alhusayen1Henrik Brandi2Mette Bøgelund3Henrik H. Jensen4Signe B. Reitzel 5Jacob P. Thyssen6Royal free London NHS Foundation Trust, London, United KingdomSunnybrook Health Sciences Centre, Division of Dermatology, Toronto, CanadaLEO Pharma A/S, Ballerup, DenmarkEY Economics Denmark, Frederiksberg, DenmarkEY Economics Denmark, Frederiksberg, DenmarkEY Economics Denmark, Frederiksberg, DenmarkLEO Pharma A/S, Ballerup, Denmark; Bispebjerg Hospital, Department for Dermatology, Copenhagen, DenmarkAtopic dermatitis is a chronic, inflammatory skin disease. A variety of systemic treatments are available for patients with moderate-to-severe atopic dermatitis. The efficacy, safety and administration profile of these treatments vary, and determining the optimal treatment strategy may require weighing the benefits and drawbacks of therapies with diverse characteristics. This study used an online discrete choice experiment survey to investigate treatment preferences among adults with atopic dermatitis from Denmark, France, the UK, or Canada. Participants were identified through existing online panels. The survey included questions regarding different treatment attributes, defined based on currently approved treatments for moderate to severe atopic dermatitis. Treatment preferences were measured as the relative importance of different treatment attributes. A total of 713 respondents met the inclusion criteria and completed the survey. The discrete choice experiment identified a significant preference for avoiding the risk of severe adverse events, and for oral pill every day compared with biweekly injections. The time to full effect was not rated as being important. These findings suggest that patients with moderate-to-severe atopic dermatitis prioritize safety as most important, followed by ease of administration in their treatment preferences, while time to full effect and monitoring requirements were the least important attributes. https://medicaljournalssweden.se/actadv/article/view/24339Adult dermatologypatient-centered carepatient participationpatient preferencestreatment preferences |
| spellingShingle | Mahreen Ameen Raed Alhusayen Henrik Brandi Mette Bøgelund Henrik H. Jensen Signe B. Reitzel Jacob P. Thyssen Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis Acta Dermato-Venereologica Adult dermatology patient-centered care patient participation patient preferences treatment preferences |
| title | Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis |
| title_full | Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis |
| title_fullStr | Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis |
| title_full_unstemmed | Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis |
| title_short | Patient Preferences in the Treatment of Moderate-to-severe Atopic Dermatitis |
| title_sort | patient preferences in the treatment of moderate to severe atopic dermatitis |
| topic | Adult dermatology patient-centered care patient participation patient preferences treatment preferences |
| url | https://medicaljournalssweden.se/actadv/article/view/24339 |
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