RA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis

RA-RAR signaling promotes mouse vaginal opening through increasing β-catenin expression and vaginal epithelial cell apoptosis

Abstract Background Retinoic acid (RA) plays important role in the maintenance and differentiation of the Müllerian ducts during the embryonic stage via RA receptors (RARs). However, the function and mechanism of RA-RAR signaling in the vaginal opening are unknown. Method We used the Rarα knockout m...

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Bibliographic Details
Main Authors: Nana Zheng, Wenbo Zhang, Xiaodan Zhang, Biao Li, Zhanying Wu, Yashuang Weng, Weiyong Wang, Jingjing Miao, Jing Yang, Meijia Zhang, Wei Xia
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
Retinoic acid receptor
Vaginal opening
Apoptosis
β-catenin
Mouse
Online Access:https://doi.org/10.1186/s12958-023-01084-8

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