Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study
(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease se...
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/8/2232 |
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| author | Matea Kuna Mario Štefanović Blaženka Ladika Davidović Nikolina Mandušić Ines Birkić Belanović Liborija Lugović-Mihić |
| author_facet | Matea Kuna Mario Štefanović Blaženka Ladika Davidović Nikolina Mandušić Ines Birkić Belanović Liborija Lugović-Mihić |
| author_sort | Matea Kuna |
| collection | DOAJ |
| description | (1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; <i>p</i> = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; <i>p</i> = 0.036) and DLQI (r = 0.504; <i>p</i> = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients. |
| first_indexed | 2024-03-11T00:06:47Z |
| format | Article |
| id | doaj.art-b028fce23e5b4f9ba994aefa8b496e5c |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T00:06:47Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b028fce23e5b4f9ba994aefa8b496e5c2023-11-19T00:21:14ZengMDPI AGBiomedicines2227-90592023-08-01118223210.3390/biomedicines11082232Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot StudyMatea Kuna0Mario Štefanović1Blaženka Ladika Davidović2Nikolina Mandušić3Ines Birkić Belanović4Liborija Lugović-Mihić5Department of Dermatovenereology, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, CroatiaDepartment of Clinical Chemistry, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, CroatiaDepartment of Oncology and Nuclear Medicine, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, CroatiaDepartment of Dermatovenereology, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, CroatiaDepartment of Dermatovenereology, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, CroatiaDepartment of Dermatovenereology, University Hospital Center “Sestre Milosrdnice”, Vinogradska 29, 10000 Zagreb, Croatia(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; <i>p</i> = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; <i>p</i> = 0.036) and DLQI (r = 0.504; <i>p</i> = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients.https://www.mdpi.com/2227-9059/11/8/2232chronic urticariabiomarkersurticaria activity scoreinflammationdisease burdenonce-daily UAS |
| spellingShingle | Matea Kuna Mario Štefanović Blaženka Ladika Davidović Nikolina Mandušić Ines Birkić Belanović Liborija Lugović-Mihić Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study Biomedicines chronic urticaria biomarkers urticaria activity score inflammation disease burden once-daily UAS |
| title | Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study |
| title_full | Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study |
| title_fullStr | Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study |
| title_full_unstemmed | Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study |
| title_short | Chronic Urticaria Biomarkers IL-6, ESR and CRP in Correlation with Disease Severity and Patient Quality of Life—A Pilot Study |
| title_sort | chronic urticaria biomarkers il 6 esr and crp in correlation with disease severity and patient quality of life a pilot study |
| topic | chronic urticaria biomarkers urticaria activity score inflammation disease burden once-daily UAS |
| url | https://www.mdpi.com/2227-9059/11/8/2232 |
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