Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature
Diarrheal disease is still a major public health concern, as it is still considered an important cause of death in children under five years of age. A few decades ago, the detection of enteropathogenic <i>E. coli</i> was made by detecting the O, H, and K antigens, mostly by agglutination...
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MDPI AG
2021-01-01
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| Series: | Gastroenterology Insights |
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| Online Access: | https://www.mdpi.com/2036-7422/12/1/4 |
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| author | Anca Delia Mare Cristina Nicoleta Ciurea Adrian Man Bianca Tudor Valeriu Moldovan Luminița Decean Felicia Toma |
| author_facet | Anca Delia Mare Cristina Nicoleta Ciurea Adrian Man Bianca Tudor Valeriu Moldovan Luminița Decean Felicia Toma |
| author_sort | Anca Delia Mare |
| collection | DOAJ |
| description | Diarrheal disease is still a major public health concern, as it is still considered an important cause of death in children under five years of age. A few decades ago, the detection of enteropathogenic <i>E. coli</i> was made by detecting the O, H, and K antigens, mostly by agglutination. The recent protocols recommend the molecular methods for diagnosing EPEC, as they can distinguish between typical and atypical EPEC by identifying the presence/absence of specific virulence factors. EPEC are defined as diarrheagenic strains of <i>E. coli</i> that can produce attaching and effacing lesions on the intestinal epithelium while being incapable of producing Shiga toxins and heat-labile or heat-stable enterotoxins. The ability of these strains to produce attaching and effacing lesions enable them to cause localized lesions by attaching tightly to the surface of the intestinal epithelial cells, disrupting the surfaces of the cells, thus leading to the effacement of the microvilli. EPEC are classified on typical and atypical isolates, based on the presence or absence of <i>E. coli</i> adherence factor plasmids. All the EPEC strains are <i>eae</i> positive; typical EPEC strains are <i>eae</i>+, <i>bfp</i>A+, while atypical strains are <i>eae</i>+, <i>bfp</i>A−. No vaccines are currently available to prevent EPEC infections. |
| first_indexed | 2024-03-09T03:32:43Z |
| format | Article |
| id | doaj.art-b02ac92aef81428e8c89b1a47efa183e |
| institution | Directory Open Access Journal |
| issn | 2036-7414 2036-7422 |
| language | English |
| last_indexed | 2024-03-09T03:32:43Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastroenterology Insights |
| spelling | doaj.art-b02ac92aef81428e8c89b1a47efa183e2023-12-03T14:53:57ZengMDPI AGGastroenterology Insights2036-74142036-74222021-01-01121284010.3390/gastroent12010004Enteropathogenic <i>Escherichia coli</i>—A Summary of the LiteratureAnca Delia Mare0Cristina Nicoleta Ciurea1Adrian Man2Bianca Tudor3Valeriu Moldovan4Luminița Decean5Felicia Toma6Department of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDepartment of Microbiology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureș, RomaniaDiarrheal disease is still a major public health concern, as it is still considered an important cause of death in children under five years of age. A few decades ago, the detection of enteropathogenic <i>E. coli</i> was made by detecting the O, H, and K antigens, mostly by agglutination. The recent protocols recommend the molecular methods for diagnosing EPEC, as they can distinguish between typical and atypical EPEC by identifying the presence/absence of specific virulence factors. EPEC are defined as diarrheagenic strains of <i>E. coli</i> that can produce attaching and effacing lesions on the intestinal epithelium while being incapable of producing Shiga toxins and heat-labile or heat-stable enterotoxins. The ability of these strains to produce attaching and effacing lesions enable them to cause localized lesions by attaching tightly to the surface of the intestinal epithelial cells, disrupting the surfaces of the cells, thus leading to the effacement of the microvilli. EPEC are classified on typical and atypical isolates, based on the presence or absence of <i>E. coli</i> adherence factor plasmids. All the EPEC strains are <i>eae</i> positive; typical EPEC strains are <i>eae</i>+, <i>bfp</i>A+, while atypical strains are <i>eae</i>+, <i>bfp</i>A−. No vaccines are currently available to prevent EPEC infections.https://www.mdpi.com/2036-7422/12/1/4diarrheal diseasetypical/atypical enteropathogenic <i>E. coli</i>virulence factorsdiagnostic |
| spellingShingle | Anca Delia Mare Cristina Nicoleta Ciurea Adrian Man Bianca Tudor Valeriu Moldovan Luminița Decean Felicia Toma Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature Gastroenterology Insights diarrheal disease typical/atypical enteropathogenic <i>E. coli</i> virulence factors diagnostic |
| title | Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature |
| title_full | Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature |
| title_fullStr | Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature |
| title_full_unstemmed | Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature |
| title_short | Enteropathogenic <i>Escherichia coli</i>—A Summary of the Literature |
| title_sort | enteropathogenic i escherichia coli i a summary of the literature |
| topic | diarrheal disease typical/atypical enteropathogenic <i>E. coli</i> virulence factors diagnostic |
| url | https://www.mdpi.com/2036-7422/12/1/4 |
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