Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept
The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and res...
| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Frontiers Media S.A.
2024-07-01
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| Edice: | Transplant International |
| Témata: | |
| On-line přístup: | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13178/full |
| _version_ | 1827173724263022592 |
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| author | Massimo Boffini Andrea Costamagna Matteo Marro Erika Simonato Paola Cassoni Luca Bertero Vito Fanelli Cristina Barbero Luca Brazzi Mauro Rinaldi |
| author_facet | Massimo Boffini Andrea Costamagna Matteo Marro Erika Simonato Paola Cassoni Luca Bertero Vito Fanelli Cristina Barbero Luca Brazzi Mauro Rinaldi |
| author_sort | Massimo Boffini |
| collection | DOAJ |
| description | The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the “Achilles’ heel” of the EVLP due to a more fluid accumulation than in the supine standard position. |
| first_indexed | 2025-03-21T03:44:12Z |
| format | Article |
| id | doaj.art-b02adb01178e4b8e901b31aa99df322b |
| institution | Directory Open Access Journal |
| issn | 1432-2277 |
| language | English |
| last_indexed | 2025-03-21T03:44:12Z |
| publishDate | 2024-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj.art-b02adb01178e4b8e901b31aa99df322b2024-07-31T04:11:09ZengFrontiers Media S.A.Transplant International1432-22772024-07-013710.3389/ti.2024.1317813178Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of ConceptMassimo Boffini0Andrea Costamagna1Matteo Marro2Erika Simonato3Paola Cassoni4Luca Bertero5Vito Fanelli6Cristina Barbero7Luca Brazzi8Mauro Rinaldi9Cardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyAnesthesiology and Intensive Care Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyCardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyCardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyPathology Unit, Medical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyPathology Unit, Medical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyAnesthesiology and Intensive Care Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyCardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyAnesthesiology and Intensive Care Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyCardiac Surgery Division, Surgical Sciences Department, Citta della Salute e della Scienza, University of Torino, Turin, ItalyThe key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the “Achilles’ heel” of the EVLP due to a more fluid accumulation than in the supine standard position.https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13178/fulllung transplantanimal modelEVLPorgan preservationperfusion |
| spellingShingle | Massimo Boffini Andrea Costamagna Matteo Marro Erika Simonato Paola Cassoni Luca Bertero Vito Fanelli Cristina Barbero Luca Brazzi Mauro Rinaldi Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept Transplant International lung transplant animal model EVLP organ preservation perfusion |
| title | Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept |
| title_full | Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept |
| title_fullStr | Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept |
| title_full_unstemmed | Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept |
| title_short | Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept |
| title_sort | orthostatic ex vivo lung perfusion evlp a proof of concept |
| topic | lung transplant animal model EVLP organ preservation perfusion |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13178/full |
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