CD4+ T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis

CD4+ T Cells Alter the Stromal Microenvironment and Repress Medullary Erythropoiesis in Murine Visceral Leishmaniasis

Human visceral leishmaniasis, a parasitic disease of major public health importance in developing countries, is characterized by variable degrees of severity of anemia, but the mechanisms underlying this change in peripheral blood have not been thoroughly explored. Here, we used an experimental mode...

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Bibliographic Details
Main Authors: Olivier Preham, Flaviane A. Pinho, Ana Isabel Pinto, Gulab Fatima Rani, Najmeeyah Brown, Ian S. Hitchcock, Hiro Goto, Paul M. Kaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
erythropoiesis
stromal cells
macrophages
bone marrow
leishmaniasis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02958/full

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