The Contributions of Extracellular Matrix and Sarcomere Properties to Passive Muscle Stiffness in Cerebral Palsy

The Contributions of Extracellular Matrix and Sarcomere Properties to Passive Muscle Stiffness in Cerebral Palsy

Cerebral palsy results from an upper motor neuron lesion and significantly affects skeletal muscle stiffness. The increased stiffness that occurs is partly a result of changes in the microstructural components of muscle. In particular, alterations in extracellular matrix, sarcomere length, fibre dia...

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Bibliographic Details
Main Authors: Ryan N. Konno, Nilima Nigam, James M. Wakeling, Stephanie A. Ross
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Physiology
Subjects:
skeletal muscle
extracellular matrix
finite element method
cerebral palsy
muscle stiffness
continuum model
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.804188/full

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