Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice
Cardiac dysfunction frequently emerges in the initial stages of cancer cachexia, posing a significant complication of the disease. Physical fitness is commonly recommended in these early stages of cancer cachexia due to its beneficial impacts on various aspects of the condition, including cardiac dy...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024015937 |
| _version_ | 1797267833370968064 |
|---|---|
| author | Lin Wang Xuchao Wang Jingyu Chen Yang Liu Gang Wang Linjian Chen Wei Ni Yijia Jia Cuilian Dai Wei Shao Binbin Liu |
| author_facet | Lin Wang Xuchao Wang Jingyu Chen Yang Liu Gang Wang Linjian Chen Wei Ni Yijia Jia Cuilian Dai Wei Shao Binbin Liu |
| author_sort | Lin Wang |
| collection | DOAJ |
| description | Cardiac dysfunction frequently emerges in the initial stages of cancer cachexia, posing a significant complication of the disease. Physical fitness is commonly recommended in these early stages of cancer cachexia due to its beneficial impacts on various aspects of the condition, including cardiac dysfunction. However, the direct functional impacts of exercise on the heart during cancer cachexia largely remain unexplored. In this study, we induced cancer cachexia in mice using a metastatic B16F10 melanoma model. Concurrently, these mice underwent a low-intensity exercise regimen to investigate its potential role in cardiac function during cachexia. Our findings indicate that exercise training can help prevent metastatic melanoma-induced muscle loss without significant alterations to body and fat weight. Moreover, exercise improved the melanoma-induced decline in left ventricular ejection fraction and fractional shortening, while also mitigating the increase in high-sensitive cardiac troponin T levels caused by metastatic melanoma in mice. Transcriptome analysis revealed that exercise significantly reversed the transcriptional alterations in the heart induced by melanoma, which were primarily enriched in pathways related to heart contraction. These results suggest that exercise can improve systolic heart function and directly influence the transcriptome of the heart during metastatic melanoma-induced cachexia. |
| first_indexed | 2024-03-08T03:12:58Z |
| format | Article |
| id | doaj.art-b02c138de810496682868470d7c12ca4 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-25T01:22:52Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b02c138de810496682868470d7c12ca42024-03-09T09:25:32ZengElsevierHeliyon2405-84402024-02-01104e25562Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in miceLin Wang0Xuchao Wang1Jingyu Chen2Yang Liu3Gang Wang4Linjian Chen5Wei Ni6Yijia Jia7Cuilian Dai8Wei Shao9Binbin Liu10Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China; Liaoning University of Traditional Chinese Medicine, Chongshan East Road 79, Shenyang 110032, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaZhoukou Central Hospital, Renmin Road 26, Zhoukou, 466000, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, ChinaXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China; Corresponding author. Xiamen Cardiovascular Hospital, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China.Xiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China; Corresponding author. Xiamen Cardiovascular Hospital, Xiamen University, Jinshan Road 2999, Xiamen, 361015, China.Cardiac dysfunction frequently emerges in the initial stages of cancer cachexia, posing a significant complication of the disease. Physical fitness is commonly recommended in these early stages of cancer cachexia due to its beneficial impacts on various aspects of the condition, including cardiac dysfunction. However, the direct functional impacts of exercise on the heart during cancer cachexia largely remain unexplored. In this study, we induced cancer cachexia in mice using a metastatic B16F10 melanoma model. Concurrently, these mice underwent a low-intensity exercise regimen to investigate its potential role in cardiac function during cachexia. Our findings indicate that exercise training can help prevent metastatic melanoma-induced muscle loss without significant alterations to body and fat weight. Moreover, exercise improved the melanoma-induced decline in left ventricular ejection fraction and fractional shortening, while also mitigating the increase in high-sensitive cardiac troponin T levels caused by metastatic melanoma in mice. Transcriptome analysis revealed that exercise significantly reversed the transcriptional alterations in the heart induced by melanoma, which were primarily enriched in pathways related to heart contraction. These results suggest that exercise can improve systolic heart function and directly influence the transcriptome of the heart during metastatic melanoma-induced cachexia.http://www.sciencedirect.com/science/article/pii/S2405844024015937Systolic functionHeartExerciseCancer cachexiaMelanoma |
| spellingShingle | Lin Wang Xuchao Wang Jingyu Chen Yang Liu Gang Wang Linjian Chen Wei Ni Yijia Jia Cuilian Dai Wei Shao Binbin Liu Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice Heliyon Systolic function Heart Exercise Cancer cachexia Melanoma |
| title | Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice |
| title_full | Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice |
| title_fullStr | Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice |
| title_full_unstemmed | Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice |
| title_short | Low-intensity exercise training improves systolic function of heart during metastatic melanoma-induced cachexia in mice |
| title_sort | low intensity exercise training improves systolic function of heart during metastatic melanoma induced cachexia in mice |
| topic | Systolic function Heart Exercise Cancer cachexia Melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024015937 |
| work_keys_str_mv | AT linwang lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT xuchaowang lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT jingyuchen lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT yangliu lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT gangwang lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT linjianchen lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT weini lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT yijiajia lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT cuiliandai lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT weishao lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice AT binbinliu lowintensityexercisetrainingimprovessystolicfunctionofheartduringmetastaticmelanomainducedcachexiainmice |