The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling
Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-relat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.952949/full |
| _version_ | 1811188475390590976 |
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| author | Kun Zhao Yukang Mao Yansong Li Chuanxi Yang Chuanxi Yang Kai Wang Jing Zhang |
| author_facet | Kun Zhao Yukang Mao Yansong Li Chuanxi Yang Chuanxi Yang Kai Wang Jing Zhang |
| author_sort | Kun Zhao |
| collection | DOAJ |
| description | Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation. |
| first_indexed | 2024-04-11T14:20:14Z |
| format | Article |
| id | doaj.art-b02caf2b223b46569f21e1d6db145031 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T14:20:14Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b02caf2b223b46569f21e1d6db1450312022-12-22T04:19:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.952949952949The roles and mechanisms of epigenetic regulation in pathological myocardial remodelingKun Zhao0Yukang Mao1Yansong Li2Chuanxi Yang3Chuanxi Yang4Kai Wang5Jing Zhang6Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaPathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.https://www.frontiersin.org/articles/10.3389/fcvm.2022.952949/fullepigenetic regulationpathological myocardial remodelingDNA methylationhistone posttranslational modificationadenosine disodium triphosphate (ATP)-dependent chromatin remodelingRNA modification |
| spellingShingle | Kun Zhao Yukang Mao Yansong Li Chuanxi Yang Chuanxi Yang Kai Wang Jing Zhang The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling Frontiers in Cardiovascular Medicine epigenetic regulation pathological myocardial remodeling DNA methylation histone posttranslational modification adenosine disodium triphosphate (ATP)-dependent chromatin remodeling RNA modification |
| title | The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| title_full | The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| title_fullStr | The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| title_full_unstemmed | The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| title_short | The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| title_sort | roles and mechanisms of epigenetic regulation in pathological myocardial remodeling |
| topic | epigenetic regulation pathological myocardial remodeling DNA methylation histone posttranslational modification adenosine disodium triphosphate (ATP)-dependent chromatin remodeling RNA modification |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.952949/full |
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