Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid
Background: Obesity among adults has risen significantly in the world-cutting across all ages, racial and ethnic groups and gender. The 5-HT 2A receptor is crucially involved in regulation of body weight and the appetite. Disturbances in the distribution and or gene regulation of the postsynaptic 5-...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Gadjah Mada
2011-10-01
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| Series: | Jurnal Gizi Klinik Indonesia |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/jgki/article/view/17772 |
| _version_ | 1828894918608683008 |
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| author | Pramudji Hastuti Nur Anisah Johan Iswara Siagian Kautsar Prastudia Eko Binuko Aidil Adhla |
| author_facet | Pramudji Hastuti Nur Anisah Johan Iswara Siagian Kautsar Prastudia Eko Binuko Aidil Adhla |
| author_sort | Pramudji Hastuti |
| collection | DOAJ |
| description | Background: Obesity among adults has risen significantly in the world-cutting across all ages, racial and ethnic groups and gender. The 5-HT 2A receptor is crucially involved in regulation of body weight and the appetite. Disturbances in the distribution and or gene regulation of the postsynaptic 5-HT2A receptor are implicated in the pathophysiology of conditions such as obesity, coronary heart disease, high blood pressure, diabetes, stroke dan some cancers.
Objective: To test the association between obesity with polymorphism of promoter -1438G→A 5-HT2A receptors gene, blood pressure, lipid profiles, levels of blood glucose and malondialdehyde (MDA).
Method: This cross-sectional study included thirty six unrelated obese young people (BMI ≥ 30) recruited from populations in Yogyakarta and 36 controls with age matched with BMI ≤ 25. Statistical differences between blood pressure, lipid profiles, glucose and MDA levels were assessed by t-test and genotypes by Chi square test.
Results: There were no significant difference in blood pressure lipid profile, level of glucose and MDA in obese group compared with control (p>0,05). Allele A and G frequency in obese group 25% and 75% respectively, and controls 22.2% and 77.8% respectively, and no significant difference in all two groups, but G allele had higher risk to obese than A allele.
Conclusion: These data indicated G allele was mild risk factor for obesity. |
| first_indexed | 2024-12-13T14:20:06Z |
| format | Article |
| id | doaj.art-b02cdc34d9a5468d8d43ea0b54ee338a |
| institution | Directory Open Access Journal |
| issn | 1693-900X 2502-4140 |
| language | Indonesian |
| last_indexed | 2024-12-13T14:20:06Z |
| publishDate | 2011-10-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Jurnal Gizi Klinik Indonesia |
| spelling | doaj.art-b02cdc34d9a5468d8d43ea0b54ee338a2022-12-21T23:42:06ZindUniversitas Gadjah MadaJurnal Gizi Klinik Indonesia1693-900X2502-41402011-10-0182818610.22146/ijcn.1777212013Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehidPramudji Hastuti0Nur Anisah1Johan Iswara Siagian2Kautsar Prastudia Eko Binuko3Aidil Adhla4Bagian Biokimia Fakultas Kedokteran Universitas Gadjah MadaBagian Histologi dan Biologi Sel Fakultas Kedokteran Universitas Gadjah MadaFakultas Kedokteran Universitas Gadjah MadaFakultas Kedokteran Universitas Gadjah MadaFakultas Kedokteran Universitas Gadjah MadaBackground: Obesity among adults has risen significantly in the world-cutting across all ages, racial and ethnic groups and gender. The 5-HT 2A receptor is crucially involved in regulation of body weight and the appetite. Disturbances in the distribution and or gene regulation of the postsynaptic 5-HT2A receptor are implicated in the pathophysiology of conditions such as obesity, coronary heart disease, high blood pressure, diabetes, stroke dan some cancers. Objective: To test the association between obesity with polymorphism of promoter -1438G→A 5-HT2A receptors gene, blood pressure, lipid profiles, levels of blood glucose and malondialdehyde (MDA). Method: This cross-sectional study included thirty six unrelated obese young people (BMI ≥ 30) recruited from populations in Yogyakarta and 36 controls with age matched with BMI ≤ 25. Statistical differences between blood pressure, lipid profiles, glucose and MDA levels were assessed by t-test and genotypes by Chi square test. Results: There were no significant difference in blood pressure lipid profile, level of glucose and MDA in obese group compared with control (p>0,05). Allele A and G frequency in obese group 25% and 75% respectively, and controls 22.2% and 77.8% respectively, and no significant difference in all two groups, but G allele had higher risk to obese than A allele. Conclusion: These data indicated G allele was mild risk factor for obesity.https://jurnal.ugm.ac.id/jgki/article/view/17772obesitastekanan darahprofil lipidreseptor 5-HT2A |
| spellingShingle | Pramudji Hastuti Nur Anisah Johan Iswara Siagian Kautsar Prastudia Eko Binuko Aidil Adhla Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid Jurnal Gizi Klinik Indonesia obesitas tekanan darah profil lipid reseptor 5-HT2A |
| title | Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid |
| title_full | Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid |
| title_fullStr | Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid |
| title_full_unstemmed | Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid |
| title_short | Obesitas dan hubungannya dengan polimorfisme gena promoter 5-HT2A, tekanan darah, profil lipid, kadar glukosa, dan malondialdehid |
| title_sort | obesitas dan hubungannya dengan polimorfisme gena promoter 5 ht2a tekanan darah profil lipid kadar glukosa dan malondialdehid |
| topic | obesitas tekanan darah profil lipid reseptor 5-HT2A |
| url | https://jurnal.ugm.ac.id/jgki/article/view/17772 |
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