Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

The bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, belongs to the most prevalent congenital heart diseases in the world, occurring in 0.5-2% of the general population. We aimed to understand how changes in early cellular contributions result in BAV formation and impa...

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Bibliographic Details
Main Authors: Joshua C. Peterson, Mary Chughtai, Lambertus J. Wisse, Adriana C. Gittenberger-de Groot, Qingping Feng, Marie-José T. H. Goumans, J. Conny VanMunsteren, Monique R. M. Jongbloed, Marco C. DeRuiter
Format: Article
Language:English
Published: The Company of Biologists 2018-10-01
Series:Disease Models & Mechanisms
Subjects:
Nos3
Bicuspid aortic valve
Lineage tracing
Embryo
Development
Outflow tract
Online Access:http://dmm.biologists.org/content/11/10/dmm034637

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