Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation

Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation

Macrophage polarization is a process whereby macrophages develop a specific phenotype and functional response to different pathophysiological stimuli and tissue environments. In general, two main macrophage phenotypes have been identified: inflammatory (M1) and alternatively activated (M2) macrophag...

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Bibliographic Details
Main Authors: Éva Garabuczi, Nastaran Tarban, Éva Fige, Andreas Patsalos, László Halász, Tímea Szendi-Szatmári, Zsolt Sarang, Róbert Király, Zsuzsa Szondy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
macrophage
PPAR gamma
Nur77
polarization
cardiotoxin
skeletal muscle injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139204/full

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