Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 d...

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Bibliographic Details
Main Authors: Yuta Hara, Tatsuma Honzawa, Moeka Kitagawa, Ritsuki Sano, Kazuhiko Matsuo, Takashi Nakayama
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Pharmacological Sciences
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Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000476
Description
Summary:Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 deficiency exacerbated depressive-like behavior. Tregs and M2 macrophages, but not Th17 cells, were decreased in the brain of CCR4-deficient mice. Consistently, treatment with a CCR4 inhibitor reduced Tregs and M2 macrophages in the brain and exacerbated depressive-like behavior. Thus, CCR4 may contribute to the reduction of depressive symptoms by promoting Treg recruitment to the brain and subsequent M2 macrophage polarization.
ISSN:1347-8613