Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice
Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861323000476 |
| _version_ | 1797672100488544256 |
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| author | Yuta Hara Tatsuma Honzawa Moeka Kitagawa Ritsuki Sano Kazuhiko Matsuo Takashi Nakayama |
| author_facet | Yuta Hara Tatsuma Honzawa Moeka Kitagawa Ritsuki Sano Kazuhiko Matsuo Takashi Nakayama |
| author_sort | Yuta Hara |
| collection | DOAJ |
| description | Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 deficiency exacerbated depressive-like behavior. Tregs and M2 macrophages, but not Th17 cells, were decreased in the brain of CCR4-deficient mice. Consistently, treatment with a CCR4 inhibitor reduced Tregs and M2 macrophages in the brain and exacerbated depressive-like behavior. Thus, CCR4 may contribute to the reduction of depressive symptoms by promoting Treg recruitment to the brain and subsequent M2 macrophage polarization. |
| first_indexed | 2024-03-11T21:25:10Z |
| format | Article |
| id | doaj.art-b030da1166644bad92b570794a6a2618 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-03-11T21:25:10Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-b030da1166644bad92b570794a6a26182023-09-28T05:25:02ZengElsevierJournal of Pharmacological Sciences1347-86132023-11-0115338993Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient miceYuta Hara0Tatsuma Honzawa1Moeka Kitagawa2Ritsuki Sano3Kazuhiko Matsuo4Takashi Nakayama5Division of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanDivision of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanCorresponding author. Division of Chemotherapy, Kindai University Faculty of Pharmacy, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.; Division of Chemotherapy, Kindai University Faculty of Pharmacy, Higashi-osaka, Osaka, JapanIncreasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 deficiency exacerbated depressive-like behavior. Tregs and M2 macrophages, but not Th17 cells, were decreased in the brain of CCR4-deficient mice. Consistently, treatment with a CCR4 inhibitor reduced Tregs and M2 macrophages in the brain and exacerbated depressive-like behavior. Thus, CCR4 may contribute to the reduction of depressive symptoms by promoting Treg recruitment to the brain and subsequent M2 macrophage polarization.http://www.sciencedirect.com/science/article/pii/S1347861323000476DepressionCCR4Treg |
| spellingShingle | Yuta Hara Tatsuma Honzawa Moeka Kitagawa Ritsuki Sano Kazuhiko Matsuo Takashi Nakayama Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice Journal of Pharmacological Sciences Depression CCR4 Treg |
| title | Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice |
| title_full | Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice |
| title_fullStr | Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice |
| title_full_unstemmed | Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice |
| title_short | Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice |
| title_sort | aggravation of lipopolysaccharide induced depressive like behavior in ccr4 deficient mice |
| topic | Depression CCR4 Treg |
| url | http://www.sciencedirect.com/science/article/pii/S1347861323000476 |
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