Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration. Here, using a lipopolysaccharide (LPS)-induced depression mouse model, we demonstrated that CCR4 d...

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Bibliographic Details
Main Authors: Yuta Hara, Tatsuma Honzawa, Moeka Kitagawa, Ritsuki Sano, Kazuhiko Matsuo, Takashi Nakayama
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Depression
CCR4
Treg
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861323000476

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