Protective effect of compatible herbs in Jin-Gu-Lian formula against Alangium chinense-induced neurotoxicity via oxidative stress, neurotransmitter metabolisms, and pharmacokinetics

Protective effect of compatible herbs in Jin-Gu-Lian formula against Alangium chinense-induced neurotoxicity via oxidative stress, neurotransmitter metabolisms, and pharmacokinetics

Background:A. chinense frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, Alangium chinense and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with co...

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Bibliographic Details
Main Authors:	Dongyin Lian, Tengfei Chen, Lihua Yan, Hongping Hou, Shuangrong Gao, Qin Hu, Guangping Zhang, Han Li, Ling Song, Yunhang Gao, Yunxi Pu, Ying Chen, Bo Peng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Pharmacology
Subjects:	Alangium chinense neurotoxicity pharmacokinetics cytochrome P450 oxidative stress neurotransmitters
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1133982/full

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