Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study

Validated LC-ESI-MS/MS method for the determination of ivosidenib in 10 µL mice plasma: application to a pharmacokinetic study

A simple, selective and rapid LC-ESI-MS/MS method has been developed and validated for the quantification of ivosidenib in mice plasma using warfarin as an internal standard (I.S.) as per regulatory guideline. Sample preparation was accomplished through a simple protein precipitation process. Chroma...

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Bibliographic Details
Main Authors: Sreekanth Dittakavi, Rakesh Kumar Jat, Sadanand Rangnathrao Mallurwar, Ravi Kumar Jairam, Ramesh Mullangi
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2019-04-01
Series:ADMET and DMPK
Subjects:
Ivosidenib
LC-MS/MS
method validation
mice plasma
pharmacokinetics
bioavailability
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/648

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