UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic

UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic

Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. I...

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Bibliographic Details
Main Authors: Zhi-Rui Yang, Zi-Hao Wang, Jin-Fa Tang, Yan Yan, Shi-Jun Yue, Wu-Wen Feng, Zheng-Yuan Shi, Xin-Tong Meng, Cheng Peng, Chang-Yun Wang, Da-Li Meng, Dan Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
Xueshuantong lyophilized powder
quality fluctuation
adverse drug reaction
UPLC-QTOF/MSE
bioassay
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00633/full

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