Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

Summary: Primordial germ cells (PGCs) are fate determined from pluripotent epiblasts. Signaling pathways and transcriptional regulators involved in PGC formation have been identified, but detailed molecular mechanisms of PGC fate determination remains poorly understood. Using RNAi screening, we iden...

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Bibliographic Details
Main Authors: Kentaro Mochizuki, Yohei Hayashi, Tamotsu Sekinaka, Kei Otsuka, Yumi Ito-Matsuoka, Hisato Kobayashi, Shinya Oki, Asuka Takehara, Tomohiro Kono, Noriko Osumi, Yasuhisa Matsui
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718312415

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