An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation
Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/22/2/319 |
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| author | Fatma S. Elsharabasy Sobhi M. Gomha Thoraya A. Farghaly Heba S. A. Elzahabi |
| author_facet | Fatma S. Elsharabasy Sobhi M. Gomha Thoraya A. Farghaly Heba S. A. Elzahabi |
| author_sort | Fatma S. Elsharabasy |
| collection | DOAJ |
| description | Novel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for antifungal activity. The antimicrobial activity profile of the tested compounds showed some promising results. The potent activity of compounds 4d, 7b (117% zone inhibition) and 7c (105% zone inhibition) against Salmonella sp., exceeding that of the reference drug Gentamycin is particularly noteworthy. In general, the newly synthesized thiazolylphthalazine derivatives showed higher antimicrobial activity against the tested Gram-negative bacteria than against Gram-positive bacteria and fungi. |
| first_indexed | 2024-04-13T08:44:42Z |
| format | Article |
| id | doaj.art-b0396daabfb44fc7975b66b20bf63e3b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T08:44:42Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b0396daabfb44fc7975b66b20bf63e3b2022-12-22T02:53:45ZengMDPI AGMolecules1420-30492017-02-0122231910.3390/molecules22020319molecules22020319An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound IrradiationFatma S. Elsharabasy0Sobhi M. Gomha1Thoraya A. Farghaly2Heba S. A. Elzahabi3Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki 12622, EgyptDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Chemistry, Faculty of Science, Cairo University, Giza 12613, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), AlAzhar University, Cairo1 1754, EgyptNovel 2-thiazolylphthalazine derivatives were efficiently synthesized under ultrasound irradiation, resulting in high yields and short reaction times after optimization of the reaction conditions. All prepared compounds were fully characterized using spectroscopic methods. They were screened for their antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for antifungal activity. The antimicrobial activity profile of the tested compounds showed some promising results. The potent activity of compounds 4d, 7b (117% zone inhibition) and 7c (105% zone inhibition) against Salmonella sp., exceeding that of the reference drug Gentamycin is particularly noteworthy. In general, the newly synthesized thiazolylphthalazine derivatives showed higher antimicrobial activity against the tested Gram-negative bacteria than against Gram-positive bacteria and fungi.http://www.mdpi.com/1420-3049/22/2/319thiazolylphthalazinedioneshydrazonoyl chloridesultrasound irradiationantimicrobial activity |
| spellingShingle | Fatma S. Elsharabasy Sobhi M. Gomha Thoraya A. Farghaly Heba S. A. Elzahabi An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation Molecules thiazolylphthalazinediones hydrazonoyl chlorides ultrasound irradiation antimicrobial activity |
| title | An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation |
| title_full | An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation |
| title_fullStr | An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation |
| title_full_unstemmed | An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation |
| title_short | An Efficient Synthesis of Novel Bioactive Thiazolyl-Phthalazinediones under Ultrasound Irradiation |
| title_sort | efficient synthesis of novel bioactive thiazolyl phthalazinediones under ultrasound irradiation |
| topic | thiazolylphthalazinediones hydrazonoyl chlorides ultrasound irradiation antimicrobial activity |
| url | http://www.mdpi.com/1420-3049/22/2/319 |
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