Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3′ untranslated region

Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3′ untranslated region

The transcription factor ONECUT2 (OC2) is a master transcriptional regulator operating in metastatic castration-resistant prostate cancer that suppresses androgen receptor activity and promotes neural differentiation and tumor cell survival. OC2 mRNA possesses an unusually long (14,575 nt), evolutio...

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Bibliographic Details
Main Authors: Kenneth Steadman, Sungyong You, Dustin V. Srinivas, Lila Mouakkad, Yiwu Yan, Minhyung Kim, Smrruthi V. Venugopal, Hisashi Tanaka, Michael R. Freeman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
competitive endogenous RNA network
neuroendocrine prostate cancer
polycomb repressing complex
androgen metabolism
prostate cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1206259/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1206259/full

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