CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer
Abstract Background Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint i...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-10882-7 |
| _version_ | 1827943403205165056 |
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| author | Danhua Xu Xu Liu Shouyu Ke Yixian Guo Chunchao Zhu Hui Cao |
| author_facet | Danhua Xu Xu Liu Shouyu Ke Yixian Guo Chunchao Zhu Hui Cao |
| author_sort | Danhua Xu |
| collection | DOAJ |
| description | Abstract Background Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors failed to achieve satisfactory results in gastric cancer. There is a need to identify novel immunotherapy targets in gastric cancer. Methods We analysed the correlation between Treg cells and CD8 + T cells in gastric cancer samples. We studied the relationship between chemokines and Treg cells or CD8 + T cells in gastric cancer. We compared CCL19/CCR7 expression in gastric cancer patients in TCGA database. We performed transwell experiments to determine the influence of CCL19 on Treg cells and CD8 + T cells migratory capacity. We conducted survival analysis of CCL19 and CCR7 in gastric cancer database. Results Treg cells show positive correlation with CD8 + T cells in gastric cancer. Treg cell expression was significantly upregulated in tumor tissues. Patients with high FOXP3 expression had worse overall survival than those with low FOXP3 expression. CCL19 had strong correlation with FOXP3 and weak correlation with CD8A. CCL19 had strong impact on the migratory capacity of Treg cells but weak impact on the migratory capacity of CD8 + T cells. Both CCL19 and CCR7 expression were significantly upregulated in gastric cancer tissues. Survival analysis demonstrated that both CCL19 and CCR7 indicate poor prognosis in gastric cancer. Conclusions CCL19/CCR7 may be a potential novel therapeutic target in gastric cancer. |
| first_indexed | 2024-03-13T10:14:57Z |
| format | Article |
| id | doaj.art-b03e36c6b68545cea0bdd2a89b94cd20 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-13T10:14:57Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-b03e36c6b68545cea0bdd2a89b94cd202023-05-21T11:18:40ZengBMCBMC Cancer1471-24072023-05-012311810.1186/s12885-023-10882-7CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancerDanhua Xu0Xu Liu1Shouyu Ke2Yixian Guo3Chunchao Zhu4Hui Cao5Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for the treatment of a variety of tumors and have achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors failed to achieve satisfactory results in gastric cancer. There is a need to identify novel immunotherapy targets in gastric cancer. Methods We analysed the correlation between Treg cells and CD8 + T cells in gastric cancer samples. We studied the relationship between chemokines and Treg cells or CD8 + T cells in gastric cancer. We compared CCL19/CCR7 expression in gastric cancer patients in TCGA database. We performed transwell experiments to determine the influence of CCL19 on Treg cells and CD8 + T cells migratory capacity. We conducted survival analysis of CCL19 and CCR7 in gastric cancer database. Results Treg cells show positive correlation with CD8 + T cells in gastric cancer. Treg cell expression was significantly upregulated in tumor tissues. Patients with high FOXP3 expression had worse overall survival than those with low FOXP3 expression. CCL19 had strong correlation with FOXP3 and weak correlation with CD8A. CCL19 had strong impact on the migratory capacity of Treg cells but weak impact on the migratory capacity of CD8 + T cells. Both CCL19 and CCR7 expression were significantly upregulated in gastric cancer tissues. Survival analysis demonstrated that both CCL19 and CCR7 indicate poor prognosis in gastric cancer. Conclusions CCL19/CCR7 may be a potential novel therapeutic target in gastric cancer.https://doi.org/10.1186/s12885-023-10882-7ChemokinesCCL19CCR7Treg cellsCD8 + T cellsGastric cancer |
| spellingShingle | Danhua Xu Xu Liu Shouyu Ke Yixian Guo Chunchao Zhu Hui Cao CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer BMC Cancer Chemokines CCL19 CCR7 Treg cells CD8 + T cells Gastric cancer |
| title | CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer |
| title_full | CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer |
| title_fullStr | CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer |
| title_full_unstemmed | CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer |
| title_short | CCL19/CCR7 drives regulatory T cell migration and indicates poor prognosis in gastric cancer |
| title_sort | ccl19 ccr7 drives regulatory t cell migration and indicates poor prognosis in gastric cancer |
| topic | Chemokines CCL19 CCR7 Treg cells CD8 + T cells Gastric cancer |
| url | https://doi.org/10.1186/s12885-023-10882-7 |
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