New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review
Abstract Background Liver diseases post-COVID-19 vaccination is extremely rare but can occur. A growing body of evidence has indicated that portal vein thrombosis, autoimmune hepatitis, raised liver enzymes and liver injuries, etc., may be potential consequence of COVID-19 vaccines. Objectives To de...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-022-02507-3 |
| _version_ | 1811238924911116288 |
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| author | Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Fatemah M. ALShakhs Om Prakash Choudhary Shin Jie Yong Firzan Nainu Amjad Khan Javed Muhammad Fadil Alhelal Mohammed Hussain Al Khamees Hussain Ahmed Alsouaib Ahmed Salman Al Majhad Hassan Redha AL-Tarfi Ali Hussain ALyasin Yaqoub Yousef Alatiyyah Ali Ahmed Alsultan Mohammed Essa Alessa Mustafa Essa Alessa Mohammed Ahmed Alissa Emad Hassan Alsayegh Hassan N. Alshakhs Haidar Abdullah Al Samaeel Rugayah Ahmed AlShayeb Dalal Ahmed Alnami Hussain Ali Alhassan Abdulaziz Abdullah Alabdullah Ayat Hussain Alhmed Faisal Hussain AlDera Khalid Hajissa Jaffar A. Al-Tawfiq Awad Al-Omari |
| author_facet | Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Fatemah M. ALShakhs Om Prakash Choudhary Shin Jie Yong Firzan Nainu Amjad Khan Javed Muhammad Fadil Alhelal Mohammed Hussain Al Khamees Hussain Ahmed Alsouaib Ahmed Salman Al Majhad Hassan Redha AL-Tarfi Ali Hussain ALyasin Yaqoub Yousef Alatiyyah Ali Ahmed Alsultan Mohammed Essa Alessa Mustafa Essa Alessa Mohammed Ahmed Alissa Emad Hassan Alsayegh Hassan N. Alshakhs Haidar Abdullah Al Samaeel Rugayah Ahmed AlShayeb Dalal Ahmed Alnami Hussain Ali Alhassan Abdulaziz Abdullah Alabdullah Ayat Hussain Alhmed Faisal Hussain AlDera Khalid Hajissa Jaffar A. Al-Tawfiq Awad Al-Omari |
| author_sort | Saad Alhumaid |
| collection | DOAJ |
| description | Abstract Background Liver diseases post-COVID-19 vaccination is extremely rare but can occur. A growing body of evidence has indicated that portal vein thrombosis, autoimmune hepatitis, raised liver enzymes and liver injuries, etc., may be potential consequence of COVID-19 vaccines. Objectives To describe the results of a systematic review for new-onset and relapsed liver disease following COVID-19 vaccination. Methods For this systematic review, we searched Proquest, Medline, Embase, PubMed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses PRISMA guideline for studies on the incidence of new onset or relapsed liver diseases post-COVID-19 vaccination, published from December 1, 2020 to July 31, 2022, with English language restriction. Results Two hundred seventy-five cases from one hundred and eighteen articles were included in the qualitative synthesis of this systematic review. Autoimmune hepatitis (138 cases) was the most frequent pathology observed post-COVID-19 vaccination, followed by portal vein thrombosis (52 cases), raised liver enzymes (26 cases) and liver injury (21 cases). Other cases include splanchnic vein thrombosis, acute cellular rejection of the liver, jaundice, hepatomegaly, acute hepatic failure and hepatic porphyria. Mortality was reported in any of the included cases for acute hepatic failure (n = 4, 50%), portal vein thrombosis (n = 25, 48.1%), splanchnic vein thrombosis (n = 6, 42.8%), jaundice (n = 1, 12.5%), raised liver enzymes (n = 2, 7.7%), and autoimmune hepatitis (n = 3, 2.2%). Most patients were easily treated without any serious complications, recovered and did not require long-term hepatic therapy. Conclusion Reported evidence of liver diseases post-COIVD-19 vaccination should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively very small in relation to the hundreds of millions of vaccinations that have occurred and the protective benefits offered by COVID-19 vaccination far outweigh the risks. |
| first_indexed | 2024-04-12T12:50:50Z |
| format | Article |
| id | doaj.art-b03fa71da8b84feba60b26cea16a334c |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-12T12:50:50Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-b03fa71da8b84feba60b26cea16a334c2022-12-22T03:32:30ZengBMCBMC Gastroenterology1471-230X2022-10-0122115410.1186/s12876-022-02507-3New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic reviewSaad Alhumaid0Abbas Al Mutair1Ali A. Rabaan2Fatemah M. ALShakhs3Om Prakash Choudhary4Shin Jie Yong5Firzan Nainu6Amjad Khan7Javed Muhammad8Fadil Alhelal9Mohammed Hussain Al Khamees10Hussain Ahmed Alsouaib11Ahmed Salman Al Majhad12Hassan Redha AL-Tarfi13Ali Hussain ALyasin14Yaqoub Yousef Alatiyyah15Ali Ahmed Alsultan16Mohammed Essa Alessa17Mustafa Essa Alessa18Mohammed Ahmed Alissa19Emad Hassan Alsayegh20Hassan N. Alshakhs21Haidar Abdullah Al Samaeel22Rugayah Ahmed AlShayeb23Dalal Ahmed Alnami24Hussain Ali Alhassan25Abdulaziz Abdullah Alabdullah26Ayat Hussain Alhmed27Faisal Hussain AlDera28Khalid Hajissa29Jaffar A. Al-Tawfiq30Awad Al-Omari31Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of HealthResearch Center, Almoosa Specialist HospitalMolecular Diagnostic Laboratory, Johns Hopkins Aramco HealthcareRespiratory Therapy Department, Prince Saud Bin Jalawi Hospital, Ministry of HealthDepartment of Veterinary Anatomy and Histology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University (I)Department of Biological Sciences, School of Medical and Life Sciences, Sunway UniversityDepartment of Pharmacy, Faculty of Pharmacy, Hasanuddin UniversityDepartment of Public Health and Nutrition, The University of HaripurDepartment of Microbiology, The University of HaripurOptometry Department, Dhahran Eye Specialist Hospital, Ministry of HealthMolecular Pathology Laboratory, King Fahad Hofuf Hospital, Ministry of HealthMedical Store Department, Maternity and Children Hospital, Ministry of HealthMedical Store Department, Maternity and Children Hospital, Ministry of HealthMedical Store Department, Maternity and Children Hospital, Ministry of HealthMedical Store Department, Maternity and Children Hospital, Ministry of HealthDepartment of Pharmacy, Hereditary Blood Diseases CentreMedical Supply Store, Aloyoon General Hospital, Ministry of HealthInventory Control Unit, Aloyoon General Hospital, Ministry of HealthPharmacy Department, Aloyoon General Hospital, Ministry of HealthPharmacy Department, Aloyoon General Hospital, Ministry of HealthPharmacy Department, Aloyoon General Hospital, Ministry of HealthPharmacy Department, Aloyoon General Hospital, Ministry of HealthPharmacy Department, Prince Saud Bin Jalawi Hospital, Ministry of HealthPharmacy Department, King Fahad Hofuf Hospital, Ministry of HealthPharmacy Department, King Fahad Hofuf Hospital, Ministry of HealthPharmacy Department, Maternity and Children Hospital, Ministry of HealthPharmacy Department, Maternity and Children Hospital, Ministry of HealthAdministration of Nursing Care, Maternity and Children Hospital, Ministry of HealthGeneral Surgery Department, King Fahad Hofuf Hospital, Ministry of HealthDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains MalaysiaInfectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco HealthcareCollege of Medicine, Alfaisal UniversityAbstract Background Liver diseases post-COVID-19 vaccination is extremely rare but can occur. A growing body of evidence has indicated that portal vein thrombosis, autoimmune hepatitis, raised liver enzymes and liver injuries, etc., may be potential consequence of COVID-19 vaccines. Objectives To describe the results of a systematic review for new-onset and relapsed liver disease following COVID-19 vaccination. Methods For this systematic review, we searched Proquest, Medline, Embase, PubMed, CINAHL, Wiley online library, Scopus and Nature through the Preferred Reporting Items for Systematic Reviews and Meta Analyses PRISMA guideline for studies on the incidence of new onset or relapsed liver diseases post-COVID-19 vaccination, published from December 1, 2020 to July 31, 2022, with English language restriction. Results Two hundred seventy-five cases from one hundred and eighteen articles were included in the qualitative synthesis of this systematic review. Autoimmune hepatitis (138 cases) was the most frequent pathology observed post-COVID-19 vaccination, followed by portal vein thrombosis (52 cases), raised liver enzymes (26 cases) and liver injury (21 cases). Other cases include splanchnic vein thrombosis, acute cellular rejection of the liver, jaundice, hepatomegaly, acute hepatic failure and hepatic porphyria. Mortality was reported in any of the included cases for acute hepatic failure (n = 4, 50%), portal vein thrombosis (n = 25, 48.1%), splanchnic vein thrombosis (n = 6, 42.8%), jaundice (n = 1, 12.5%), raised liver enzymes (n = 2, 7.7%), and autoimmune hepatitis (n = 3, 2.2%). Most patients were easily treated without any serious complications, recovered and did not require long-term hepatic therapy. Conclusion Reported evidence of liver diseases post-COIVD-19 vaccination should not discourage vaccination against this worldwide pandemic. The number of reported cases is relatively very small in relation to the hundreds of millions of vaccinations that have occurred and the protective benefits offered by COVID-19 vaccination far outweigh the risks.https://doi.org/10.1186/s12876-022-02507-3SARS-CoV-2COVID-19DiseaseHepaticLiverPathology |
| spellingShingle | Saad Alhumaid Abbas Al Mutair Ali A. Rabaan Fatemah M. ALShakhs Om Prakash Choudhary Shin Jie Yong Firzan Nainu Amjad Khan Javed Muhammad Fadil Alhelal Mohammed Hussain Al Khamees Hussain Ahmed Alsouaib Ahmed Salman Al Majhad Hassan Redha AL-Tarfi Ali Hussain ALyasin Yaqoub Yousef Alatiyyah Ali Ahmed Alsultan Mohammed Essa Alessa Mustafa Essa Alessa Mohammed Ahmed Alissa Emad Hassan Alsayegh Hassan N. Alshakhs Haidar Abdullah Al Samaeel Rugayah Ahmed AlShayeb Dalal Ahmed Alnami Hussain Ali Alhassan Abdulaziz Abdullah Alabdullah Ayat Hussain Alhmed Faisal Hussain AlDera Khalid Hajissa Jaffar A. Al-Tawfiq Awad Al-Omari New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review BMC Gastroenterology SARS-CoV-2 COVID-19 Disease Hepatic Liver Pathology |
| title | New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review |
| title_full | New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review |
| title_fullStr | New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review |
| title_full_unstemmed | New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review |
| title_short | New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review |
| title_sort | new onset and relapsed liver diseases following covid 19 vaccination a systematic review |
| topic | SARS-CoV-2 COVID-19 Disease Hepatic Liver Pathology |
| url | https://doi.org/10.1186/s12876-022-02507-3 |
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