Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells
Functional hydrogels with properties that mimic the structure of extracellular matrix (ECM) and regulate cell behaviors have drawn much attention in biomedical applications. Herein, gelatin-based hydrogels were designed and loaded with chondroitin sulfate (CS) to endow biological regulation on the a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/5/261 |
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| author | Haonan Wang Qian Li Yongchao Jiang Xiaofeng Wang |
| author_facet | Haonan Wang Qian Li Yongchao Jiang Xiaofeng Wang |
| author_sort | Haonan Wang |
| collection | DOAJ |
| description | Functional hydrogels with properties that mimic the structure of extracellular matrix (ECM) and regulate cell behaviors have drawn much attention in biomedical applications. Herein, gelatin-based hydrogels were designed and loaded with chondroitin sulfate (CS) to endow biological regulation on the angiogenesis behaviors of endothelial cells (ECs). Manufactured hydrogels containing various amounts of CS were characterized via methods including mechanical tests, cytocompatibility, hemolysis, and angiogenesis assays. The results showed that the prepared hydrogels exhibited excellent mechanical stability, cytocompatibility, and hemocompatibility. Additionally, the angiogenesis behaviors of ECs were obviously promoted. However, excessive loading of CS would weaken the effect due to a higher proportion of occupation on the cell membrane. In conclusion, this investigation highlights the great potential of these hydrogels in treating ischemic diseases and accelerating tissue regeneration in terms of regulating the angiogenesis process via CS release. |
| first_indexed | 2024-03-10T03:51:33Z |
| format | Article |
| id | doaj.art-b03fd4813c3042bb96646e39c8b0ba4e |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T03:51:33Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-b03fd4813c3042bb96646e39c8b0ba4e2023-11-23T11:04:44ZengMDPI AGGels2310-28612022-04-018526110.3390/gels8050261Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial CellsHaonan Wang0Qian Li1Yongchao Jiang2Xiaofeng Wang3School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, ChinaFunctional hydrogels with properties that mimic the structure of extracellular matrix (ECM) and regulate cell behaviors have drawn much attention in biomedical applications. Herein, gelatin-based hydrogels were designed and loaded with chondroitin sulfate (CS) to endow biological regulation on the angiogenesis behaviors of endothelial cells (ECs). Manufactured hydrogels containing various amounts of CS were characterized via methods including mechanical tests, cytocompatibility, hemolysis, and angiogenesis assays. The results showed that the prepared hydrogels exhibited excellent mechanical stability, cytocompatibility, and hemocompatibility. Additionally, the angiogenesis behaviors of ECs were obviously promoted. However, excessive loading of CS would weaken the effect due to a higher proportion of occupation on the cell membrane. In conclusion, this investigation highlights the great potential of these hydrogels in treating ischemic diseases and accelerating tissue regeneration in terms of regulating the angiogenesis process via CS release.https://www.mdpi.com/2310-2861/8/5/261hydrogelchondroitin sulfateendothelial cellangiogenesis |
| spellingShingle | Haonan Wang Qian Li Yongchao Jiang Xiaofeng Wang Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells Gels hydrogel chondroitin sulfate endothelial cell angiogenesis |
| title | Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells |
| title_full | Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells |
| title_fullStr | Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells |
| title_full_unstemmed | Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells |
| title_short | Functional Hydrogels with Chondroitin Sulfate Release Properties Regulate the Angiogenesis Behaviors of Endothelial Cells |
| title_sort | functional hydrogels with chondroitin sulfate release properties regulate the angiogenesis behaviors of endothelial cells |
| topic | hydrogel chondroitin sulfate endothelial cell angiogenesis |
| url | https://www.mdpi.com/2310-2861/8/5/261 |
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