Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis
Abstract Background Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in pat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-024-03310-y |
| _version_ | 1797274394557415424 |
|---|---|
| author | Chenming Liu Liang An Siyuan Zhang Shiqing Deng Neng Wang Haijun Tang |
| author_facet | Chenming Liu Liang An Siyuan Zhang Shiqing Deng Neng Wang Haijun Tang |
| author_sort | Chenming Liu |
| collection | DOAJ |
| description | Abstract Background Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery. Methods Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software. Results A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P < 0.00001) and PFS (HR = 1.55, P < 0.00001). However, this association was not obvious in regard to the incidence of major complications (OR = 1.33, P = 0.11). Conclusion Preoperative sarcopenia was preliminarily proved to be associated with the terrible prognosis of pancreatic cancer after surgery. However, this relationship needs to be further validated in more prospective studies. |
| first_indexed | 2024-03-07T14:58:42Z |
| format | Article |
| id | doaj.art-b03ffa9bf0504e5c958b944d157f0d11 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-07T14:58:42Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-b03ffa9bf0504e5c958b944d157f0d112024-03-05T19:18:45ZengBMCWorld Journal of Surgical Oncology1477-78192024-01-0122111210.1186/s12957-024-03310-yAssociation between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysisChenming Liu0Liang An1Siyuan Zhang2Shiqing Deng3Neng Wang4Haijun Tang5Department of Hepatopancreatobiliary Surgery, Shaoxing People’s HospitalDepartment of Gastrointestinal Surgery, Shaoxing People’s HospitalDepartment of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical UniversityDepartment of Breast and Thyroid Surgery, General Hospital of Huainan Eastern Hospital GroupDepartment of Hepatopancreatobiliary Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Hepatopancreatobiliary Surgery, Shaoxing People’s HospitalAbstract Background Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery. Methods Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software. Results A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P < 0.00001) and PFS (HR = 1.55, P < 0.00001). However, this association was not obvious in regard to the incidence of major complications (OR = 1.33, P = 0.11). Conclusion Preoperative sarcopenia was preliminarily proved to be associated with the terrible prognosis of pancreatic cancer after surgery. However, this relationship needs to be further validated in more prospective studies.https://doi.org/10.1186/s12957-024-03310-ySarcopeniaPancreatic neoplasmPrognosisMeta-analysis |
| spellingShingle | Chenming Liu Liang An Siyuan Zhang Shiqing Deng Neng Wang Haijun Tang Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis World Journal of Surgical Oncology Sarcopenia Pancreatic neoplasm Prognosis Meta-analysis |
| title | Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis |
| title_full | Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis |
| title_fullStr | Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis |
| title_full_unstemmed | Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis |
| title_short | Association between preoperative sarcopenia and prognosis of pancreatic cancer after curative-intent surgery: a updated systematic review and meta-analysis |
| title_sort | association between preoperative sarcopenia and prognosis of pancreatic cancer after curative intent surgery a updated systematic review and meta analysis |
| topic | Sarcopenia Pancreatic neoplasm Prognosis Meta-analysis |
| url | https://doi.org/10.1186/s12957-024-03310-y |
| work_keys_str_mv | AT chenmingliu associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis AT liangan associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis AT siyuanzhang associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis AT shiqingdeng associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis AT nengwang associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis AT haijuntang associationbetweenpreoperativesarcopeniaandprognosisofpancreaticcanceraftercurativeintentsurgeryaupdatedsystematicreviewandmetaanalysis |