Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus
The genome of Muju virus (MUJV), identified originally in the royal vole (Myodes regulus) in Korea, was fully sequenced to ascertain its genetic and phylogenetic relationship with Puumala virus (PUUV), harbored by the bank vole (My. glareolus), and a PUUV-like virus, named Hokkaido virus (HOKV), in...
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| Format: | Article |
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MDPI AG
2014-04-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/6/4/1701 |
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| author | Jin Goo Lee Se Hun Gu Luck Ju Baek Ok Sarah Shin Kwang Sook Park Heung-Chul Kim Terry A. Klein Richard Yanagihara Jin-Won Song |
| author_facet | Jin Goo Lee Se Hun Gu Luck Ju Baek Ok Sarah Shin Kwang Sook Park Heung-Chul Kim Terry A. Klein Richard Yanagihara Jin-Won Song |
| author_sort | Jin Goo Lee |
| collection | DOAJ |
| description | The genome of Muju virus (MUJV), identified originally in the royal vole (Myodes regulus) in Korea, was fully sequenced to ascertain its genetic and phylogenetic relationship with Puumala virus (PUUV), harbored by the bank vole (My. glareolus), and a PUUV-like virus, named Hokkaido virus (HOKV), in the grey red-backed vole (My. rufocanus) in Japan. Whole genome sequence analysis of the 6544-nucleotide large (L), 3652-nucleotide medium (M) and 1831-nucleotide small (S) segments of MUJV, as well as the amino acid sequences of their gene products, indicated that MUJV strains from different capture sites might represent genetic variants of PUUV, the prototype arvicolid rodent-borne hantavirus in Europe. Distinct geographic-specific clustering of MUJV was found in different provinces in Korea, and phylogenetic analyses revealed that MUJV and HOKV share a common ancestry with PUUV. A better understanding of the taxonomic classification and pathogenic potential of MUJV must await its isolation in cell culture. |
| first_indexed | 2024-12-23T05:20:41Z |
| format | Article |
| id | doaj.art-b043a6cf1d5b46a28feeb63a7505e311 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-23T05:20:41Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b043a6cf1d5b46a28feeb63a7505e3112022-12-21T17:58:43ZengMDPI AGViruses1999-49152014-04-01641701171410.3390/v6041701v6041701Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne HantavirusJin Goo Lee0Se Hun Gu1Luck Ju Baek2Ok Sarah Shin3Kwang Sook Park4Heung-Chul Kim5Terry A. Klein6Richard Yanagihara7Jin-Won Song8Department of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, KoreaDepartment of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, KoreaDepartment of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, KoreaDepartment of Biomedical Science, College of Medicine, Korea University, Seoul 136-705, KoreaDepartment of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, KoreaMedical Detachment, 168th Multifunctional Medical Battalion, 65th Medical Brigade, Unit 15247, APO AP 96205-5247, USAPublic Health Command Region-Pacific, 65th Medical Brigade, Unit 15281, APO AP 96205-5281, USAPacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USADepartment of Microbiology, College of Medicine, and the Institute for Viral Diseases, Korea University, Seoul 136-705, KoreaThe genome of Muju virus (MUJV), identified originally in the royal vole (Myodes regulus) in Korea, was fully sequenced to ascertain its genetic and phylogenetic relationship with Puumala virus (PUUV), harbored by the bank vole (My. glareolus), and a PUUV-like virus, named Hokkaido virus (HOKV), in the grey red-backed vole (My. rufocanus) in Japan. Whole genome sequence analysis of the 6544-nucleotide large (L), 3652-nucleotide medium (M) and 1831-nucleotide small (S) segments of MUJV, as well as the amino acid sequences of their gene products, indicated that MUJV strains from different capture sites might represent genetic variants of PUUV, the prototype arvicolid rodent-borne hantavirus in Europe. Distinct geographic-specific clustering of MUJV was found in different provinces in Korea, and phylogenetic analyses revealed that MUJV and HOKV share a common ancestry with PUUV. A better understanding of the taxonomic classification and pathogenic potential of MUJV must await its isolation in cell culture.http://www.mdpi.com/1999-4915/6/4/1701hantavirusMyodes regulusMuju virusphylogeny |
| spellingShingle | Jin Goo Lee Se Hun Gu Luck Ju Baek Ok Sarah Shin Kwang Sook Park Heung-Chul Kim Terry A. Klein Richard Yanagihara Jin-Won Song Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus Viruses hantavirus Myodes regulus Muju virus phylogeny |
| title | Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus |
| title_full | Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus |
| title_fullStr | Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus |
| title_full_unstemmed | Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus |
| title_short | Muju Virus, Harbored by Myodes regulus in Korea, Might Represent a Genetic Variant of Puumala Virus, the Prototype Arvicolid Rodent-Borne Hantavirus |
| title_sort | muju virus harbored by myodes regulus in korea might represent a genetic variant of puumala virus the prototype arvicolid rodent borne hantavirus |
| topic | hantavirus Myodes regulus Muju virus phylogeny |
| url | http://www.mdpi.com/1999-4915/6/4/1701 |
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