Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study
Objective: To investigate the effect of combined repetitive peripheral magnetic stimulation and transcranial magnetic stimulation on upper extremity function in subacute stroke patients. Design: Pilot study. Subjects: Subacute stroke patients. Methods: Included patients were randomized into 3 gro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2024-02-01
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| Series: | Journal of Rehabilitation Medicine |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/jrm/article/view/19449 |
| _version_ | 1797336254214307840 |
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| author | Sijie Liang Weining Wang Fengyun Yu Li Pan Dongyan Xu Ruiping Hu Shan Tian Jie Xiang Yulian Zhu |
| author_facet | Sijie Liang Weining Wang Fengyun Yu Li Pan Dongyan Xu Ruiping Hu Shan Tian Jie Xiang Yulian Zhu |
| author_sort | Sijie Liang |
| collection | DOAJ |
| description | Objective: To investigate the effect of combined repetitive peripheral magnetic stimulation and transcranial magnetic stimulation on upper extremity function in subacute stroke patients.
Design: Pilot study.
Subjects: Subacute stroke patients.
Methods: Included patients were randomized into 3 groups: a central-associated peripheral stimulation (CPS) group, a central-stimulation-only (CS) group, and a control (C) group. The CPS group underwent a new paired associative stimulation (combined repetitive peripheral magnetic stimulation and transcranial magnetic stimulation), the CS group underwent repetitive transcranial magnetic stimulation, and the C group underwent sham stimulation. All 3 groups received physiotherapy after the stimulation or sham stimulation. The treatment comprised 20 once-daily sessions. Primary outcome was the Fugl-Meyer Assessment Upper Extremity (FMA-UE) score, and secondary outcomes were the Barthel Index and Comprehensive Functional Assessment scores, and neurophysiological assessments were mainly short-interval intracortical inhibition. A 3-group (CPS, CS, C) × 2-time (before, after intervention) repeated measures analysis of variance was conducted to determine whether changes in scores were significantly different between the 3 groups.
Results: A total of 45 patients were included in the analysis. Between-group comparisons on the FMA-UE demonstrated a significant improvement (group × time interaction, F2,42 = 4.86; p = 0.013; C vs CS, p = 0.020; C vs CPS, p = 0.016; CS vs CPS, p = 0.955). Correlation analysis did not find any substantial positive correlation between changes in FMA-UE and short-interval intracortical inhibition variables (C, r = –0.196, p = 0.483; CS, r = –0.169, p = 0.546; CPS, r = –0.424, p = 0.115).
Conclusion: This study suggests that the real-stimulus (CS and CPS) groups had better outcomes than the control (C) group. In addition, the CPS group showed a better trend in clinical and neurophysiological assessments compared with the CS group.
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| first_indexed | 2024-03-08T08:51:34Z |
| format | Article |
| id | doaj.art-b0446611a51d464788a358b0c20a52c7 |
| institution | Directory Open Access Journal |
| issn | 1651-2081 |
| language | English |
| last_indexed | 2024-03-08T08:51:34Z |
| publishDate | 2024-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Journal of Rehabilitation Medicine |
| spelling | doaj.art-b0446611a51d464788a358b0c20a52c72024-02-01T08:45:47ZengMedical Journals SwedenJournal of Rehabilitation Medicine1651-20812024-02-015610.2340/jrm.v56.19449Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot studySijie Liang0Weining Wang1Fengyun Yu2Li Pan3Dongyan Xu4Ruiping Hu5Shan Tian6Jie Xiang7Yulian Zhu8Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China; Department of Rehabilitation Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaObjective: To investigate the effect of combined repetitive peripheral magnetic stimulation and transcranial magnetic stimulation on upper extremity function in subacute stroke patients. Design: Pilot study. Subjects: Subacute stroke patients. Methods: Included patients were randomized into 3 groups: a central-associated peripheral stimulation (CPS) group, a central-stimulation-only (CS) group, and a control (C) group. The CPS group underwent a new paired associative stimulation (combined repetitive peripheral magnetic stimulation and transcranial magnetic stimulation), the CS group underwent repetitive transcranial magnetic stimulation, and the C group underwent sham stimulation. All 3 groups received physiotherapy after the stimulation or sham stimulation. The treatment comprised 20 once-daily sessions. Primary outcome was the Fugl-Meyer Assessment Upper Extremity (FMA-UE) score, and secondary outcomes were the Barthel Index and Comprehensive Functional Assessment scores, and neurophysiological assessments were mainly short-interval intracortical inhibition. A 3-group (CPS, CS, C) × 2-time (before, after intervention) repeated measures analysis of variance was conducted to determine whether changes in scores were significantly different between the 3 groups. Results: A total of 45 patients were included in the analysis. Between-group comparisons on the FMA-UE demonstrated a significant improvement (group × time interaction, F2,42 = 4.86; p = 0.013; C vs CS, p = 0.020; C vs CPS, p = 0.016; CS vs CPS, p = 0.955). Correlation analysis did not find any substantial positive correlation between changes in FMA-UE and short-interval intracortical inhibition variables (C, r = –0.196, p = 0.483; CS, r = –0.169, p = 0.546; CPS, r = –0.424, p = 0.115). Conclusion: This study suggests that the real-stimulus (CS and CPS) groups had better outcomes than the control (C) group. In addition, the CPS group showed a better trend in clinical and neurophysiological assessments compared with the CS group. https://medicaljournalssweden.se/jrm/article/view/19449ipsilateral hemispheremotor cortex excitabilitymotor functionpaired associative stimulationrepetitive peripheral magnetic stimulationrepetitive transcranial magnetic stimulation |
| spellingShingle | Sijie Liang Weining Wang Fengyun Yu Li Pan Dongyan Xu Ruiping Hu Shan Tian Jie Xiang Yulian Zhu Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study Journal of Rehabilitation Medicine ipsilateral hemisphere motor cortex excitability motor function paired associative stimulation repetitive peripheral magnetic stimulation repetitive transcranial magnetic stimulation |
| title | Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study |
| title_full | Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study |
| title_fullStr | Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study |
| title_full_unstemmed | Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study |
| title_short | Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study |
| title_sort | repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke a pilot study |
| topic | ipsilateral hemisphere motor cortex excitability motor function paired associative stimulation repetitive peripheral magnetic stimulation repetitive transcranial magnetic stimulation |
| url | https://medicaljournalssweden.se/jrm/article/view/19449 |
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