Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker
Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficien...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2013-01-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.9.13 |
| _version_ | 1819062898223218688 |
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| author | Mayeul Collot Steffen Eller Markus Weishaupt Peter H. Seeberger |
| author_facet | Mayeul Collot Steffen Eller Markus Weishaupt Peter H. Seeberger |
| author_sort | Mayeul Collot |
| collection | DOAJ |
| description | Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found. |
| first_indexed | 2024-12-21T15:06:05Z |
| format | Article |
| id | doaj.art-b0456ee9449b4191888481c2ed9bfaa3 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-21T15:06:05Z |
| publishDate | 2013-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-b0456ee9449b4191888481c2ed9bfaa32022-12-21T18:59:26ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-01-01919710510.3762/bjoc.9.131860-5397-9-13Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linkerMayeul Collot0Steffen Eller1Markus Weishaupt2Peter H. Seeberger3Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyDepartment of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, GermanyAutomated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found.https://doi.org/10.3762/bjoc.9.13glycosylationhydrogenolysislinkersoligosaccharidesresinssolid-phase synthesis |
| spellingShingle | Mayeul Collot Steffen Eller Markus Weishaupt Peter H. Seeberger Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker Beilstein Journal of Organic Chemistry glycosylation hydrogenolysis linkers oligosaccharides resins solid-phase synthesis |
| title | Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker |
| title_full | Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker |
| title_fullStr | Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker |
| title_full_unstemmed | Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker |
| title_short | Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker |
| title_sort | glycosylation efficiencies on different solid supports using a hydrogenolysis labile linker |
| topic | glycosylation hydrogenolysis linkers oligosaccharides resins solid-phase synthesis |
| url | https://doi.org/10.3762/bjoc.9.13 |
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