Time from sudden sensory neural hearing loss to treatment as a prognostic factor
IntroductionThe widely accepted treatment for sudden sensorineural hearing loss (SSNHL) is corticosteroid treatment (oral or intratympanic). The main goal of this work is to define the significance of the time between symptom onset and treatment initiation, as well as other prognostic factors, for h...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1158955/full |
| _version_ | 1797847179678711808 |
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| author | Itay Chen Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Ronen Perez Chanan Shaul |
| author_facet | Itay Chen Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Ronen Perez Chanan Shaul |
| author_sort | Itay Chen |
| collection | DOAJ |
| description | IntroductionThe widely accepted treatment for sudden sensorineural hearing loss (SSNHL) is corticosteroid treatment (oral or intratympanic). The main goal of this work is to define the significance of the time between symptom onset and treatment initiation, as well as other prognostic factors, for hearing improvement.MethodsThis retrospective study included 666 patients treated for SSNHL. Demographic data, audiometry, treatment method, time since symptom onset, and associated symptoms were recorded for each patient. The patients were divided into five groups according to the treatment initiation time—half a week, one week, 2 weeks, 3 weeks, or 4 weeks and over—after symptom onset. The degree of improvement was assessed by comparing the audiometry at the beginning and the end of the treatment.ResultsThe average period of hearing loss from symptom onset to treatment initiation was 10.8 days. Significant differences were found between the groups of half a week, one week, and 2 weeks and the groups of 3 weeks and 4 weeks and over (each separately, p < 0.001). No difference was found between the half-week, one-week, and two-week groups, nor was there a difference between the three-week and four-week-and-over groups. A correlation was found between the treatment initiation time in days and the degree of improvement in hearing for both speech recognition threshold (SRT) and discrimination, R = 0.26 p < 0.001 and R = 0.17 p < 0.001, respectively. No correlation was found for gender, age of the patients, comorbidities, or associated symptoms.ConclusionThe threshold for treatment initiation time is up to 2 weeks, after which the amplitude of hearing improvement decreases significantly. The other prognostic factors measured were not found to be statistically significant predictors. |
| first_indexed | 2024-04-09T18:07:07Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T18:07:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-b0464374655e4550b34debcc53ef477b2023-04-14T05:39:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11589551158955Time from sudden sensory neural hearing loss to treatment as a prognostic factorItay ChenShalom EligalOri MenahemRiki SalemJean-Yves SichelRonen PerezChanan ShaulIntroductionThe widely accepted treatment for sudden sensorineural hearing loss (SSNHL) is corticosteroid treatment (oral or intratympanic). The main goal of this work is to define the significance of the time between symptom onset and treatment initiation, as well as other prognostic factors, for hearing improvement.MethodsThis retrospective study included 666 patients treated for SSNHL. Demographic data, audiometry, treatment method, time since symptom onset, and associated symptoms were recorded for each patient. The patients were divided into five groups according to the treatment initiation time—half a week, one week, 2 weeks, 3 weeks, or 4 weeks and over—after symptom onset. The degree of improvement was assessed by comparing the audiometry at the beginning and the end of the treatment.ResultsThe average period of hearing loss from symptom onset to treatment initiation was 10.8 days. Significant differences were found between the groups of half a week, one week, and 2 weeks and the groups of 3 weeks and 4 weeks and over (each separately, p < 0.001). No difference was found between the half-week, one-week, and two-week groups, nor was there a difference between the three-week and four-week-and-over groups. A correlation was found between the treatment initiation time in days and the degree of improvement in hearing for both speech recognition threshold (SRT) and discrimination, R = 0.26 p < 0.001 and R = 0.17 p < 0.001, respectively. No correlation was found for gender, age of the patients, comorbidities, or associated symptoms.ConclusionThe threshold for treatment initiation time is up to 2 weeks, after which the amplitude of hearing improvement decreases significantly. The other prognostic factors measured were not found to be statistically significant predictors.https://www.frontiersin.org/articles/10.3389/fneur.2023.1158955/fullhearing losscorticosteoridsaudiogramintratymapnic injectiondiscrimination |
| spellingShingle | Itay Chen Shalom Eligal Ori Menahem Riki Salem Jean-Yves Sichel Ronen Perez Chanan Shaul Time from sudden sensory neural hearing loss to treatment as a prognostic factor Frontiers in Neurology hearing loss corticosteorids audiogram intratymapnic injection discrimination |
| title | Time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| title_full | Time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| title_fullStr | Time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| title_full_unstemmed | Time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| title_short | Time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| title_sort | time from sudden sensory neural hearing loss to treatment as a prognostic factor |
| topic | hearing loss corticosteorids audiogram intratymapnic injection discrimination |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1158955/full |
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