Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Abstract Background Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. Object...

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Main Authors: Marcin F. Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H. Chaudry, Craig M. Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V. Kozlov, Claude Libert, John C. Marshall, Lyle L. Moldawer, Peter Radermacher, Heinz Redl, Daniel G. Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, Willem Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
Format: Article
Language:English
Published: SpringerOpen 2018-08-01
Series:Intensive Care Medicine Experimental
Subjects:
Guidelines
Experiment
Study design
Humane modeling
Infection types
Organ dysfunction
Online Access:http://link.springer.com/article/10.1186/s40635-018-0189-y

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