1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking

1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking

Targeting the VEGFR-2 signaling pathway is an inveterate approach toward combating pancreatic and hepatocellular cancers. Based on Sunitinib, the FDA-approved VEGFR-2 inhibitor, novel indolin-2-one-triazole hybrids were designed and synthesized as anti-hepatocellular and anti-pancreatic cancer agent...

Full description

Bibliographic Details
Main Authors:	Ahmed E. Elsawi, Mai I. Shahin, Hager A. Elbendary, Tarfah Al-Warhi, Fatma E. Hassan, Wagdy M. Eldehna
Format:	Article
Language:	English
Published:	MDPI AG 2024-01-01
Series:	Pharmaceuticals
Subjects:	angiogenesis anti-cancer agents synthesis molecular modeling tail approach
Online Access:	https://www.mdpi.com/1424-8247/17/1/81

Similar Items

An overview on 2-indolinone derivatives as anticancer agents
by: Samy M. Ibrahim, et al.
Published: (2024-01-01)

Identification of Novel Cyanopyridones and Pyrido[2,3-<em>d</em>]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
by: Tarfah Al-Warhi, et al.
Published: (2022-10-01)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
by: Moataz A. Shaldam, et al.
Published: (2023-12-01)

Electrochemical Synthesis of Versatile Pyrimidine and Oxadiazoles Tethered Triazoles as Inhibitors of VEGFR-2 in Human Breast Cancer Cells
by: Akshay Ravish, et al.
Published: (2023-10-01)

Tail Docking of Piglets 2: Effects of Meloxicam on the Stress Response to Tail Docking
by: Rebecca Morrison, et al.
Published: (2020-09-01)

Synthesis, antimycobacterial evaluation, and molecular docking study of 1,2,4-triazole derivatives
by: Meng-Yu Xia, et al.
Published: (2023-12-01)

Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant <i>Mycobacterium tuberculosis</i>
by: Mohamed A. Abdelrahman, et al.
Published: (2022-12-01)

Tandem transformations of 1,2,4-triazol-5-ylidenes into 5-amidino-1,2,4-triazoles
by: Nikolai I. Korotkikh, et al.
Published: (2007-12-01)

Unexpected Synthesis, Single-Crystal X-ray Structure, Anticancer Activity, and Molecular Docking Studies of Certain 2–((Imidazole/Benzimidazol–2–yl)thio)–1–arylethanones
by: Tarfah Al-Warhi, et al.
Published: (2020-05-01)

Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
by: Mohamed A. Mahmoud, et al.
Published: (2024-12-01)

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies
by: Eslam B. Elkaeed, et al.
Published: (2022-09-01)

New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies
by: Zbigniew Karczmarzyk, et al.
Published: (2020-12-01)

1,2,4-Triazoles as Important Antibacterial Agents
by: Małgorzata Strzelecka, et al.
Published: (2021-03-01)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway.
by: Mohammed S Taghour, et al.
Published: (2022-01-01)

Antioxidant activity of novel 4H- chromene tethered 1,2,3-Triazole Analogues: Synthesis and molecular docking studies
by: Shalini Aitha, et al.
Published: (2023-01-01)

Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease
by: Mai H. ElNaggar, et al.
Published: (2023-12-01)

Novel 1,2,3-Triazole-Coumarin Hybrid Glycosides and Their Tetrazolyl Analogues: Design, Anticancer Evaluation and Molecular Docking Targeting EGFR, VEGFR-2 and CDK-2
by: Wael A. El-Sayed, et al.
Published: (2022-03-01)

Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-d] pyrimidines
by: Ameen Ali Abu-Hashem, et al.
Published: (2024-03-01)

Tail Docking of Piglets 1: Stress Response of Piglets to Tail Docking
by: Rebecca Morrison, et al.
Published: (2020-09-01)

Synthesis of some New 1,2,4-Triazole derivatives
by: Ibtehal Kahtan Abdullah
Published: (2013-11-01)

Discovery of novel 1,2,4-triazole tethered β-hydroxy sulfides as bacterial tyrosinase inhibitors: synthesis and biophysical evaluation through in vitro and in silico approaches
by: Saeed, Sadaf, et al.
Published: (2024)

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles
by: Per H.J. Carlsen, et al.
Published: (2001-11-01)

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Series of Bis-1,2,4-Triazoles as Thymidine Phosphorylase Inhibitor
by: Korol N, et al.
Published: (2023-08-01)

Greek Pig Farmers’ Perceptions and Experiences of Tail Biting and Tail Docking
by: Michail Kakanis, et al.
Published: (2023-02-01)

Synthesis of substituted 2-(1,2,4- triazol-3-yl)benzimidazoles
by: N. V. Ivanova, et al.
Published: (2006-10-01)

Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11β-HSD1 Inhibitors
by: Doaa A. Osman, et al.
Published: (2021-09-01)

Synthesis, molecular docking, and ADME analysis of a series of 4-amino-3,5-dimethyl-1,2,4-triazole derivatives
by: L. I. Kucherenko, et al.
Published: (2023-07-01)

Crystal Structures And Analysis Of 1,2,4 Triazole And Pyrazole Compounds
by: Goh , Jia Hao
Published: (2011)

Proton-Conducting Polymeric Membranes Based on 1,2,4-Triazole
by: Galina F. Prozorova, et al.
Published: (2023-01-01)

Synthesis of 5-oxymethyl-1,2,4-triazole-3-carboxamides
by: L. E. Grebenkina, et al.
Published: (2022-09-01)

Theoretical Study of Tautomeric Conformations for 1,2,4-Triazole Derivatives
by: Radia Mahboub
Published: (2021-03-01)

Analysis of the domestic market of 1,2,4-triazole-containing drugs
by: M. V. Ohloblina, et al.
Published: (2022-08-01)

Determination of antimicrobial activity of some 1,2,4-triazole derivatives
by: M. S. M. Alrawashdeh
Published: (2018-04-01)

Behaviour of tail-docked lambs tested in isolation
by: Marchewka Joanna, et al.
Published: (2016-12-01)

Tail Lesions and Losses of Docked and Undocked Pigs in Different Farrowing and Rearing Systems
by: Maria Gentz, et al.
Published: (2020-04-01)

Combination of 1,2,3-triazole and 1,2,4-triazole frameworks for new high-energy and low-sensitivity compounds
by: Wenjing Yao, et al.
Published: (2021-06-01)

Exploring theophylline-1,2,4-triazole tethered N-phenylacetamide derivatives as antimicrobial agents: unraveling mechanisms via structure-activity relationship, in vitro validation, and in silico insights
by: Sadaf Saeed, et al.
Published: (2024-04-01)

Repositioning of acefylline as anti-cancer drug: Synthesis, anticancer and computational studies of azomethines derived from acefylline tethered 4-amino-3-mercapto-1,2,4-triazole.
by: Irum Shahzadi, et al.
Published: (2022-01-01)

Repositioning of acefylline as anti-cancer drug: Synthesis, anticancer and computational studies of azomethines derived from acefylline tethered 4-amino-3-mercapto-1,2,4-triazole
by: Irum Shahzadi, et al.
Published: (2022-01-01)

Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole
by: Baghdad Science Journal
Published: (2009-03-01)