High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department
Objective The objective of this study was to test the hypothesis that an elevated high-sensitivity C-reactive protein (hs-CRP)/albumin ratio at admission increases the risk of mortality in older patients admitted to the hospital via the emergency department (ED). Methods We performed a retrospective...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2017-03-01
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| Series: | Clinical and Experimental Emergency Medicine |
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| Online Access: | http://www.ceemjournal.org/upload/pdf/ceem-16-158.pdf |
| _version_ | 1797897175345135616 |
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| author | Jaehun Oh Soo Hyun Kim Kyu Nam Park Sang Hoon Oh Young Min Kim Han Joon Kim Chun Song Youn |
| author_facet | Jaehun Oh Soo Hyun Kim Kyu Nam Park Sang Hoon Oh Young Min Kim Han Joon Kim Chun Song Youn |
| author_sort | Jaehun Oh |
| collection | DOAJ |
| description | Objective The objective of this study was to test the hypothesis that an elevated high-sensitivity C-reactive protein (hs-CRP)/albumin ratio at admission increases the risk of mortality in older patients admitted to the hospital via the emergency department (ED). Methods We performed a retrospective analysis of patients admitted to the ED with any medical problem between May 2013 and October 2013 who were older than 65 years. The hs-CRP and albumin levels were measured at the time of admission to the ED. The primary outcome was all-cause in-hospital mortality. Multivariate logistic analysis was performed. Results A total of 811 patients were finally included in this study. The mean age was 76±7 years, and 438 subjects (54%) were male. The in-hospital mortality rate was 9.0% (73 patients). The hs-CRP/albumin ratio was higher in nonsurvivors than in survivors (34.2±37.6 vs. 16.2±25.5, P<0.001). Multivariate logistic analysis showed that the hs-CRP/albumin ratio was associated with all-cause in-hospital mortality after adjusting for other confounding factors (odds ratio, 1.011; 95% confidence interval [CI], 1.003 to 1.020). The prognostic value of the hs-CRP/albumin ratio for predicting mortality (area under the curve, 0.728; 95% CI, 0.696 to 0.758) was greater than that of hs-CRP alone (area under the curve, 0.706; 95% CI, 0.674 to 0.738; P<0.001). Conclusion The hs-CRP/albumin ratio at admission to the ED is associated with all-cause in-hospital mortality among patients older than 65 years. The hs-CRP/albumin ratio may serve as a surrogate marker of disease severity. |
| first_indexed | 2024-04-10T07:54:31Z |
| format | Article |
| id | doaj.art-b0477dfdb2fc43a08377ee02db9512ee |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:54:31Z |
| publishDate | 2017-03-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-b0477dfdb2fc43a08377ee02db9512ee2023-02-23T05:54:02ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252017-03-0141192410.15441/ceem.16.158125High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency departmentJaehun Oh0Soo Hyun Kim1Kyu Nam Park2Sang Hoon Oh3Young Min Kim4Han Joon Kim5Chun Song Youn6 Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea College of Medicine, Seoul, KoreaObjective The objective of this study was to test the hypothesis that an elevated high-sensitivity C-reactive protein (hs-CRP)/albumin ratio at admission increases the risk of mortality in older patients admitted to the hospital via the emergency department (ED). Methods We performed a retrospective analysis of patients admitted to the ED with any medical problem between May 2013 and October 2013 who were older than 65 years. The hs-CRP and albumin levels were measured at the time of admission to the ED. The primary outcome was all-cause in-hospital mortality. Multivariate logistic analysis was performed. Results A total of 811 patients were finally included in this study. The mean age was 76±7 years, and 438 subjects (54%) were male. The in-hospital mortality rate was 9.0% (73 patients). The hs-CRP/albumin ratio was higher in nonsurvivors than in survivors (34.2±37.6 vs. 16.2±25.5, P<0.001). Multivariate logistic analysis showed that the hs-CRP/albumin ratio was associated with all-cause in-hospital mortality after adjusting for other confounding factors (odds ratio, 1.011; 95% confidence interval [CI], 1.003 to 1.020). The prognostic value of the hs-CRP/albumin ratio for predicting mortality (area under the curve, 0.728; 95% CI, 0.696 to 0.758) was greater than that of hs-CRP alone (area under the curve, 0.706; 95% CI, 0.674 to 0.738; P<0.001). Conclusion The hs-CRP/albumin ratio at admission to the ED is associated with all-cause in-hospital mortality among patients older than 65 years. The hs-CRP/albumin ratio may serve as a surrogate marker of disease severity.http://www.ceemjournal.org/upload/pdf/ceem-16-158.pdfmortalityagedc-reactive proteinalbumins |
| spellingShingle | Jaehun Oh Soo Hyun Kim Kyu Nam Park Sang Hoon Oh Young Min Kim Han Joon Kim Chun Song Youn High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department Clinical and Experimental Emergency Medicine mortality aged c-reactive protein albumins |
| title | High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department |
| title_full | High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department |
| title_fullStr | High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department |
| title_full_unstemmed | High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department |
| title_short | High-sensitivity C-reactive protein/albumin ratio as a predictor of in-hospital mortality in older adults admitted to the emergency department |
| title_sort | high sensitivity c reactive protein albumin ratio as a predictor of in hospital mortality in older adults admitted to the emergency department |
| topic | mortality aged c-reactive protein albumins |
| url | http://www.ceemjournal.org/upload/pdf/ceem-16-158.pdf |
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