Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck
The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2020-07-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/522 |
| _version_ | 1797876169764241408 |
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| author | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko |
| author_facet | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko |
| author_sort | L. V. Bolotina |
| collection | DOAJ |
| description | The results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice. |
| first_indexed | 2024-04-10T01:58:56Z |
| format | Article |
| id | doaj.art-b048da499da94939b7645edc7f4ba6eb |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T01:58:56Z |
| publishDate | 2020-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-b048da499da94939b7645edc7f4ba6eb2023-03-13T08:43:21ZrusABV-pressОпухоли головы и шеи2222-14682411-46342020-07-01102102110.17650/2222-1468-2020-10-2-10-21388Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neckL. V. Bolotina0T. I. Deshkina1A. L. Kornietskaya2S. A. Kravtsov3T. V. Ustinova4A. A. Paychadze5A. D. Kaprin6А. А. Fedenko7Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииГБУЗ «Городская клиническая онкологическая больница № 1 Департамента здравоохранения г. Москвы»Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииThe results of the clinical studies have a direct impact on clinical practice. The main criteria for the effectiveness of treatment method are increasing the overall life expectancy and improving its quality. In the treatment of common forms of squamous cell carcinoma of the head and neck, induction chemotherapy can be used, including platinum drugs, preferably in combination with cetuximab. Next immuno-oncological drugs should be prescribed. In the future, in the 1st line of therapy, it is possible to replace cetuximab with pembrolizumab or monotherapy with pembrolizumab, which allows to increase the effectiveness of treatment and reduce its toxicity. The article presents 3 clinical observations that demonstrate the possibility of integration the results of clinical research in practice.https://ogsh.abvpress.ru/jour/article/view/522плоскоклеточный рак головы и шеиплатиносодержащая химиотерапияиммуноонкологические препаратыниволумабпембролизумаблекарственная терапия 1-й линииэкспрессия pd-l1 |
| spellingShingle | L. V. Bolotina T. I. Deshkina A. L. Kornietskaya S. A. Kravtsov T. V. Ustinova A. A. Paychadze A. D. Kaprin А. А. Fedenko Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck Опухоли головы и шеи плоскоклеточный рак головы и шеи платиносодержащая химиотерапия иммуноонкологические препараты ниволумаб пембролизумаб лекарственная терапия 1-й линии экспрессия pd-l1 |
| title | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_full | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_fullStr | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_full_unstemmed | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_short | Influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| title_sort | influence of the results of international studies on the choice of treatment tactics for unresectable forms of squamous cell carcinoma of the head and neck |
| topic | плоскоклеточный рак головы и шеи платиносодержащая химиотерапия иммуноонкологические препараты ниволумаб пембролизумаб лекарственная терапия 1-й линии экспрессия pd-l1 |
| url | https://ogsh.abvpress.ru/jour/article/view/522 |
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