Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/2/232 |
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| author | May Nasser Bin-Jumah Muhammad Shahid Nadeem Sadaf Jamal Gilani Bismillah Mubeen Inam Ullah Sami I. Alzarea Mohammed M. Ghoneim Sultan Alshehri Fahad A. Al-Abbasi Imran Kazmi |
| author_facet | May Nasser Bin-Jumah Muhammad Shahid Nadeem Sadaf Jamal Gilani Bismillah Mubeen Inam Ullah Sami I. Alzarea Mohammed M. Ghoneim Sultan Alshehri Fahad A. Al-Abbasi Imran Kazmi |
| author_sort | May Nasser Bin-Jumah |
| collection | DOAJ |
| description | Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension. |
| first_indexed | 2024-03-09T22:45:45Z |
| format | Article |
| id | doaj.art-b0493d0e05cc4909bd4cd25c8ef95386 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T22:45:45Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b0493d0e05cc4909bd4cd25c8ef953862023-11-23T18:30:30ZengMDPI AGAntioxidants2076-39212022-01-0111223210.3390/antiox11020232Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular DiseasesMay Nasser Bin-Jumah0Muhammad Shahid Nadeem1Sadaf Jamal Gilani2Bismillah Mubeen3Inam Ullah4Sami I. Alzarea5Mohammed M. Ghoneim6Sultan Alshehri7Fahad A. Al-Abbasi8Imran Kazmi9Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Basic Health Sciences, Preparatory Year, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaInstitute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54000, PakistanInstitute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54000, PakistanDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaLycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension.https://www.mdpi.com/2076-3921/11/2/232lycopenenutraceuticalreactive oxygen speciescoronary artery diseasehypertension |
| spellingShingle | May Nasser Bin-Jumah Muhammad Shahid Nadeem Sadaf Jamal Gilani Bismillah Mubeen Inam Ullah Sami I. Alzarea Mohammed M. Ghoneim Sultan Alshehri Fahad A. Al-Abbasi Imran Kazmi Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases Antioxidants lycopene nutraceutical reactive oxygen species coronary artery disease hypertension |
| title | Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases |
| title_full | Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases |
| title_fullStr | Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases |
| title_full_unstemmed | Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases |
| title_short | Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases |
| title_sort | lycopene a natural arsenal in the war against oxidative stress and cardiovascular diseases |
| topic | lycopene nutraceutical reactive oxygen species coronary artery disease hypertension |
| url | https://www.mdpi.com/2076-3921/11/2/232 |
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