SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies
SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/3/534 |
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| author | María Noel Badano Matias J. Pereson Florencia Sabbione Irene Keitelman Natalia Aloisi Roberto Chuit María M. E. de Bracco Susana Fink Patricia Baré |
| author_facet | María Noel Badano Matias J. Pereson Florencia Sabbione Irene Keitelman Natalia Aloisi Roberto Chuit María M. E. de Bracco Susana Fink Patricia Baré |
| author_sort | María Noel Badano |
| collection | DOAJ |
| description | SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase in systemic antibodies, which were higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose three occurred and boosted antibody levels in the salivary compartment. These results suggest that current vaccination strategies against COVID-19 should be improved. Results also showed that determination of salivary antibodies against SARS-CoV-2 could be a valuable tool in disease prevalence studies, for the follow-up of vaccinated individuals, and to assist vaccination strategies against COVID-19, especially in settings where blood sampling cannot be fulfilled. |
| first_indexed | 2024-03-11T05:48:26Z |
| format | Article |
| id | doaj.art-b04acb344b894a29a6d5290da3675646 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T05:48:26Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b04acb344b894a29a6d5290da36756462023-11-17T14:17:24ZengMDPI AGVaccines2076-393X2023-02-0111353410.3390/vaccines11030534SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood AntibodiesMaría Noel Badano0Matias J. Pereson1Florencia Sabbione2Irene Keitelman3Natalia Aloisi4Roberto Chuit5María M. E. de Bracco6Susana Fink7Patricia Baré8Instituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires 1113, ArgentinaInstituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Investigaciones Hematológicas (IIHEMA), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Investigaciones Epidemiológicas (IIE), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaInstituto de Medicina Experimental (IMEX)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires 1425, ArgentinaSARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase in systemic antibodies, which were higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose three occurred and boosted antibody levels in the salivary compartment. These results suggest that current vaccination strategies against COVID-19 should be improved. Results also showed that determination of salivary antibodies against SARS-CoV-2 could be a valuable tool in disease prevalence studies, for the follow-up of vaccinated individuals, and to assist vaccination strategies against COVID-19, especially in settings where blood sampling cannot be fulfilled.https://www.mdpi.com/2076-393X/11/3/534SARS-CoV-2 breakthrough infectionsvaccinesanti-spike antibody levelshumoral responseIgG specific salivary antibodies |
| spellingShingle | María Noel Badano Matias J. Pereson Florencia Sabbione Irene Keitelman Natalia Aloisi Roberto Chuit María M. E. de Bracco Susana Fink Patricia Baré SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies Vaccines SARS-CoV-2 breakthrough infections vaccines anti-spike antibody levels humoral response IgG specific salivary antibodies |
| title | SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies |
| title_full | SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies |
| title_fullStr | SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies |
| title_full_unstemmed | SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies |
| title_short | SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies |
| title_sort | sars cov 2 breakthrough infections after third doses boost igg specific salivary and blood antibodies |
| topic | SARS-CoV-2 breakthrough infections vaccines anti-spike antibody levels humoral response IgG specific salivary antibodies |
| url | https://www.mdpi.com/2076-393X/11/3/534 |
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