Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity

Mitochondria-mediated ferroptosis induced by CARD9 ablation prevents MDSCs-dependent antifungal immunity

Abstract Background Caspase Recruitment Domain-containing protein 9 (CARD9) expressed in myeloid cells has been demonstrated to play an antifungal immunity role in protecting against disseminated candidiasis. Hereditary CARD9 ablation leads to fatal disseminated candidiasis. However, the myeloid cel...

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Bibliographic Details
Main Authors: Zhiyong Zhang, Pengfei Li, Ying Chen, Yuxi Chen, Xiuzhu Wang, Sunan Shen, Yue Zhao, Yanan Zhu, Tingting Wang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
CARD9
Disseminated candidiasis
MDSCs
SLC7A11
Ferroptosis
Mitochondrial OXPHOS
Online Access:https://doi.org/10.1186/s12964-024-01581-2

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