Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients
Abstract Background Information processing speed is commonly impaired in people with multiple sclerosis (PwMS). However, depression and fatigue can affect the cognitive profile of patients: fatigue has a negative impact from the disease’s earliest stage and a reduced information processing speed is...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Psychology |
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| Online Access: | https://doi.org/10.1186/s40359-023-01235-x |
| _version_ | 1797778656230113280 |
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| author | Madia M. Biasi Alessia Manni Ilaria Pepe Chiara Abbatantuono Daphne Gasparre Pietro Iaffaldano Marta Simone Maria F. De Caro Maria Trojano Paolo Taurisano Damiano Paolicelli |
| author_facet | Madia M. Biasi Alessia Manni Ilaria Pepe Chiara Abbatantuono Daphne Gasparre Pietro Iaffaldano Marta Simone Maria F. De Caro Maria Trojano Paolo Taurisano Damiano Paolicelli |
| author_sort | Madia M. Biasi |
| collection | DOAJ |
| description | Abstract Background Information processing speed is commonly impaired in people with multiple sclerosis (PwMS). However, depression and fatigue can affect the cognitive profile of patients: fatigue has a negative impact from the disease’s earliest stage and a reduced information processing speed is often associated with higher levels of depression. Therefore, the aim of this study was to investigate the correlations between information processing speed and physical fatigue in a cohort of Italian PwMS from a single center, considering the effect of depression. Methods Two hundred (W = 128; mean age = 39.83 years; SD = 11.86) PwMS, from the Bari University Hospital, underwent testing for processing speed (Symbol Digit Modalities Test [SDMT]), fatigue level (Fatigue Severity Scale [FSS]), and depression (Beck’s Depression Inventory [BDI]). Results Statistically significant correlations emerged between SDMT and FSS, SDMT and BDI, FSS and BDI. Mediation analyses revealed that while physical fatigue had no significant direct negative effect on information processing speed (z=-0.891; p > 0.05), depression predicted the relationship between fatigue and information processing speed (z=-2.181; p < 0.05). Conclusion Our findings showed that cognitive performance at SDMT was not affected by patients’ perceived level of physical fatigue, but by depression. The presence of a high BDI score mediates the physical fatigue on cognitive performance impact. |
| first_indexed | 2024-03-12T23:19:41Z |
| format | Article |
| id | doaj.art-b04dd8edb8de40468747d53b2805ea90 |
| institution | Directory Open Access Journal |
| issn | 2050-7283 |
| language | English |
| last_indexed | 2024-03-12T23:19:41Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychology |
| spelling | doaj.art-b04dd8edb8de40468747d53b2805ea902023-07-16T11:31:51ZengBMCBMC Psychology2050-72832023-07-011111710.1186/s40359-023-01235-xImpact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patientsMadia M. Biasi0Alessia Manni1Ilaria Pepe2Chiara Abbatantuono3Daphne Gasparre4Pietro Iaffaldano5Marta Simone6Maria F. De Caro7Maria Trojano8Paolo Taurisano9Damiano Paolicelli10Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Department of Translational Biomedicine and Neuroscience, University of Bari “Aldo Moro”Abstract Background Information processing speed is commonly impaired in people with multiple sclerosis (PwMS). However, depression and fatigue can affect the cognitive profile of patients: fatigue has a negative impact from the disease’s earliest stage and a reduced information processing speed is often associated with higher levels of depression. Therefore, the aim of this study was to investigate the correlations between information processing speed and physical fatigue in a cohort of Italian PwMS from a single center, considering the effect of depression. Methods Two hundred (W = 128; mean age = 39.83 years; SD = 11.86) PwMS, from the Bari University Hospital, underwent testing for processing speed (Symbol Digit Modalities Test [SDMT]), fatigue level (Fatigue Severity Scale [FSS]), and depression (Beck’s Depression Inventory [BDI]). Results Statistically significant correlations emerged between SDMT and FSS, SDMT and BDI, FSS and BDI. Mediation analyses revealed that while physical fatigue had no significant direct negative effect on information processing speed (z=-0.891; p > 0.05), depression predicted the relationship between fatigue and information processing speed (z=-2.181; p < 0.05). Conclusion Our findings showed that cognitive performance at SDMT was not affected by patients’ perceived level of physical fatigue, but by depression. The presence of a high BDI score mediates the physical fatigue on cognitive performance impact.https://doi.org/10.1186/s40359-023-01235-xMultiple sclerosisCognitionInformation processing speed, depression, fatigue |
| spellingShingle | Madia M. Biasi Alessia Manni Ilaria Pepe Chiara Abbatantuono Daphne Gasparre Pietro Iaffaldano Marta Simone Maria F. De Caro Maria Trojano Paolo Taurisano Damiano Paolicelli Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients BMC Psychology Multiple sclerosis Cognition Information processing speed, depression, fatigue |
| title | Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| title_full | Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| title_fullStr | Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| title_full_unstemmed | Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| title_short | Impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| title_sort | impact of depression on the perception of fatigue and information processing speed in a cohort of multiple sclerosis patients |
| topic | Multiple sclerosis Cognition Information processing speed, depression, fatigue |
| url | https://doi.org/10.1186/s40359-023-01235-x |
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