Functional state of kidneys in patients with clinical manifestations of hypothyroidism
The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ß, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods – The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The cl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2013-05-01
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| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | http://www.romj.org/node/64 |
| _version_ | 1819131100851601408 |
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| author | Marina M. Orlova T.I. Rodionova |
| author_facet | Marina M. Orlova T.I. Rodionova |
| author_sort | Marina M. Orlova |
| collection | DOAJ |
| description | The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ß, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods – The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results – The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentrational kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokineMCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion – It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression. |
| first_indexed | 2024-12-22T09:10:09Z |
| format | Article |
| id | doaj.art-b04f181ca43d48c28c7116ede72b99c9 |
| institution | Directory Open Access Journal |
| issn | 2304-3415 |
| language | English |
| last_indexed | 2024-12-22T09:10:09Z |
| publishDate | 2013-05-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj.art-b04f181ca43d48c28c7116ede72b99c92022-12-21T18:31:27ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152013-05-01220204Functional state of kidneys in patients with clinical manifestations of hypothyroidismMarina M. OrlovaT.I. RodionovaThe research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1ß, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods – The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results – The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters of the concentrational kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokineMCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion – It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression.http://www.romj.org/node/64thyroid hormonesrenal functionspeed of glomerular filtration |
| spellingShingle | Marina M. Orlova T.I. Rodionova Functional state of kidneys in patients with clinical manifestations of hypothyroidism Russian Open Medical Journal thyroid hormones renal function speed of glomerular filtration |
| title | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_full | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_fullStr | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_full_unstemmed | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_short | Functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| title_sort | functional state of kidneys in patients with clinical manifestations of hypothyroidism |
| topic | thyroid hormones renal function speed of glomerular filtration |
| url | http://www.romj.org/node/64 |
| work_keys_str_mv | AT marinamorlova functionalstateofkidneysinpatientswithclinicalmanifestationsofhypothyroidism AT tirodionova functionalstateofkidneysinpatientswithclinicalmanifestationsofhypothyroidism |