Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China
ABSTRACT: Objectives: Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. Klebsiella pneumoniae (K. pneumoniae) is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of K. pneumoniae–induced...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Global Antimicrobial Resistance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716523002370 |
| _version_ | 1797249165552517120 |
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| author | Jinqing Liu Yao Liu Chunhui Li Wenting Peng Chuan Jiang Shifang Peng Lei Fu |
| author_facet | Jinqing Liu Yao Liu Chunhui Li Wenting Peng Chuan Jiang Shifang Peng Lei Fu |
| author_sort | Jinqing Liu |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. Klebsiella pneumoniae (K. pneumoniae) is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of K. pneumoniae–induced pyogenic liver abscess (KP-PLA), particularly those caused by carbapenem-resistant K. pneumoniae (CRKP). Methods: Analyses were performed on PLA patients from January 2010 to December 2021, to investigate the differences of K. pneumoniae from other etiologically infected PLA patients. Univariate and multivariate logistic regression analyses were used to compare prognostic factors between patients with carbapenem-resistant K. pneumoniae PLA (CRKP-PLA) and patients with carbapenem-sensitive K. pneumoniae PLA. Results: Univariate analysis demonstrated a significant association between KP-PLA and factors including diabetes mellitus (P < 0.001), cholecystitis and cholelithiasis (P = 0.032), single abscess (P = 0.016), and abscesses with a diameter over 50 mm (P = 0.004). The CRKP group exhibited a higher prevalence of therapeutic interventions before K. pneumoniae infection, including abdominal surgery, mechanical ventilation, sputum suction, tracheal cannula, routine drainage of the abdominal cavity, and peripherally inserted central venous catheters (P < 0.05). Multivariate logistic regression analysis revealed that admission to the intensive care unit was an independent risk factor associated with CRKP-PLA (odds ratio 36; 95% confidence interval 1.77–731.56; P = 0.020). Conclusion: The KP-PLA patients were significantly associated with diabetes and were more likely to have single abscesses larger than 50 mm. PLA patients with a history of admission to intensive care unit or invasive therapeutic procedures should be given special consideration if combined with CRKP infection. |
| first_indexed | 2024-03-08T11:26:03Z |
| format | Article |
| id | doaj.art-b0528408204d47c38a9ed43f17777dc7 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-04-24T20:26:09Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-b0528408204d47c38a9ed43f17777dc72024-03-22T05:39:29ZengElsevierJournal of Global Antimicrobial Resistance2213-71652024-03-0136210216Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South ChinaJinqing Liu0Yao Liu1Chunhui Li2Wenting Peng3Chuan Jiang4Shifang Peng5Lei Fu6Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaCentre for Healthcare-Associated Infection Control, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Correspondence author. Mailing address: 87 Xiangya Road, Kaifu District, Changsha, Hunan, China.ABSTRACT: Objectives: Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. Klebsiella pneumoniae (K. pneumoniae) is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of K. pneumoniae–induced pyogenic liver abscess (KP-PLA), particularly those caused by carbapenem-resistant K. pneumoniae (CRKP). Methods: Analyses were performed on PLA patients from January 2010 to December 2021, to investigate the differences of K. pneumoniae from other etiologically infected PLA patients. Univariate and multivariate logistic regression analyses were used to compare prognostic factors between patients with carbapenem-resistant K. pneumoniae PLA (CRKP-PLA) and patients with carbapenem-sensitive K. pneumoniae PLA. Results: Univariate analysis demonstrated a significant association between KP-PLA and factors including diabetes mellitus (P < 0.001), cholecystitis and cholelithiasis (P = 0.032), single abscess (P = 0.016), and abscesses with a diameter over 50 mm (P = 0.004). The CRKP group exhibited a higher prevalence of therapeutic interventions before K. pneumoniae infection, including abdominal surgery, mechanical ventilation, sputum suction, tracheal cannula, routine drainage of the abdominal cavity, and peripherally inserted central venous catheters (P < 0.05). Multivariate logistic regression analysis revealed that admission to the intensive care unit was an independent risk factor associated with CRKP-PLA (odds ratio 36; 95% confidence interval 1.77–731.56; P = 0.020). Conclusion: The KP-PLA patients were significantly associated with diabetes and were more likely to have single abscesses larger than 50 mm. PLA patients with a history of admission to intensive care unit or invasive therapeutic procedures should be given special consideration if combined with CRKP infection.http://www.sciencedirect.com/science/article/pii/S2213716523002370Carbapenem-resistant Klebsiella pneumoniaePyogenic liver abscessIntensive care unit |
| spellingShingle | Jinqing Liu Yao Liu Chunhui Li Wenting Peng Chuan Jiang Shifang Peng Lei Fu Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China Journal of Global Antimicrobial Resistance Carbapenem-resistant Klebsiella pneumoniae Pyogenic liver abscess Intensive care unit |
| title | Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China |
| title_full | Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China |
| title_fullStr | Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China |
| title_full_unstemmed | Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China |
| title_short | Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China |
| title_sort | characteristics of klebsiella pneumoniae pyogenic liver abscess from 2010 2021 in a tertiary teaching hospital of south china |
| topic | Carbapenem-resistant Klebsiella pneumoniae Pyogenic liver abscess Intensive care unit |
| url | http://www.sciencedirect.com/science/article/pii/S2213716523002370 |
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