Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm

Pasteurella multocida activates apoptosis via the FAK-AKT-FOXO1 axis to cause pulmonary integrity loss, bacteremia, and eventually a cytokine storm

Abstract Pasteurella multocida is an important zoonotic respiratory pathogen capable of infecting a diverse range of hosts, including humans, farm animals, and wild animals. However, the precise mechanisms by which P. multocida compromises the pulmonary integrity of mammals and subsequently induces...

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Bibliographic Details
Main Authors: Guangfu Zhao, Yunhan Tang, Ruitong Dan, Muhan Xie, Tianci Zhang, Pan Li, Fang He, Nengzhang Li, Yuanyi Peng
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Veterinary Research
Subjects:
Pasteurella multocida
apoptosis
pathogenesis
FAK-AKT-FOXO1 axis
pneumonia
pulmonary integrity
Online Access:https://doi.org/10.1186/s13567-024-01298-7

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