The Human Fetal and Adult Stem Cell Secretome Can Exert Cardioprotective Paracrine Effects against Cardiotoxicity and Oxidative Stress from Cancer Treatment

The Human Fetal and Adult Stem Cell Secretome Can Exert Cardioprotective Paracrine Effects against Cardiotoxicity and Oxidative Stress from Cancer Treatment

Cardiovascular side effects are major shortcomings of cancer treatments causing cardiotoxicity and late-onset cardiomyopathy. While doxorubicin (Dox) has been reported as an effective chemotherapy agent, unspecific impairment in cardiomyocyte mitochondria activity has been documented. We demonstrate...

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Bibliographic Details
Main Authors: Federico Villa, Silvia Bruno, Ambra Costa, Mingchuan Li, Michele Russo, James Cimino, Paola Altieri, Clarissa Ruggeri, Cansu Gorgun, Pierangela De Biasio, Dario Paladini, Domenico Coviello, Rodolfo Quarto, Pietro Ameri, Alessandra Ghigo, Silvia Ravera, Roberta Tasso, Sveva Bollini
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
stem cell
paracrine effect
cardiomyocyte
doxorubicin
cardiotoxicity
mitochondria
Online Access:https://www.mdpi.com/2072-6694/13/15/3729

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