Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti

Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti

Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial for identifying potential pharmacological target...

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Bibliographic Details
Main Authors: Marijana Sekulic-Jablanovic, Matthew B. Wright, Vesna Petkovic, Daniel Bodmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inflammation
ototoxicity
gentamicin
cochlea
PPARγ
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.566148/full

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