Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression
Abstract Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and clinical profiles underlying aggress...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04255-w |
| _version_ | 1797998260151910400 |
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| author | Hongxin Deng Lei He Chong Wang Teng Zhang Hua Guo Hongwei Zhang Yanning Song Bangtao Chen |
| author_facet | Hongxin Deng Lei He Chong Wang Teng Zhang Hua Guo Hongwei Zhang Yanning Song Bangtao Chen |
| author_sort | Hongxin Deng |
| collection | DOAJ |
| description | Abstract Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and clinical profiles underlying aggression in schizophrenia (ScZ). Methods Serum and stool specimens from ScZ inpatients with (ScZ-Ag, 25 cases) and without aggression (NScZ-Ag, 25 cases) were collected. Systemic inflammation, oxidation and leaky gut biomarkers were determined by ELISA, gut microbiota by 16S rRNA sequencing, short-chain fatty acids (SCFAs) by gas chromatography-mass spectrometry analysis and neurotransmitters by liquid chromatograph mass spectrometry analysis. Results Significantly higher systemic pro-inflammation, pro-oxidation and leaky gut biomarkers were observed in ScZ-Ag than NScZ-Ag group (all P<0.001). Compared to NScZ-Ag group, the alpha-diversity and evenness of fecal bacterial community were much lower, the abundance of fecal genera Prevotella was significantly increased, while that Bacteroides, Faecalibacterium, Blautia, Bifidobacterium,Collinsella and Eubacterium_coprostanoligenes were remarkably reduced in ScZ-Ag group (all corrected P<0.001). Meanwhile, 6 SCFAs and 6 neurotransmitters were much lower in ScZ-Ag group (all P<0.05). Finally, a few strongly positive or negative correlations among altered gut microbiota, SCFAs, systemic pro-inflammation, leaky gut, pro-oxidation and aggression severity were detected. Conclusions These results demonstrate that pro-inflammation, pro-oxidation and leaky gut phenotypes relating to enteric dysbacteriosis and microbial SCFAs feature the aggression onset or severity in ScZ individuals. |
| first_indexed | 2024-04-11T10:45:50Z |
| format | Article |
| id | doaj.art-b059acd516e447549baaf948537d4ae8 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-11T10:45:50Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-b059acd516e447549baaf948537d4ae82022-12-22T04:29:03ZengBMCBMC Psychiatry1471-244X2022-09-0122111210.1186/s12888-022-04255-wAltered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggressionHongxin Deng0Lei He1Chong Wang2Teng Zhang3Hua Guo4Hongwei Zhang5Yanning Song6Bangtao Chen7Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Psychiatry, Zhumadian Psychiatric Hospital (The Second People’s Hospital of Zhumadian)Department of Dermatology, Chongqing University Three Gorges Hospital, School of Medicine, Chong UniversityAbstract Background The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and clinical profiles underlying aggression in schizophrenia (ScZ). Methods Serum and stool specimens from ScZ inpatients with (ScZ-Ag, 25 cases) and without aggression (NScZ-Ag, 25 cases) were collected. Systemic inflammation, oxidation and leaky gut biomarkers were determined by ELISA, gut microbiota by 16S rRNA sequencing, short-chain fatty acids (SCFAs) by gas chromatography-mass spectrometry analysis and neurotransmitters by liquid chromatograph mass spectrometry analysis. Results Significantly higher systemic pro-inflammation, pro-oxidation and leaky gut biomarkers were observed in ScZ-Ag than NScZ-Ag group (all P<0.001). Compared to NScZ-Ag group, the alpha-diversity and evenness of fecal bacterial community were much lower, the abundance of fecal genera Prevotella was significantly increased, while that Bacteroides, Faecalibacterium, Blautia, Bifidobacterium,Collinsella and Eubacterium_coprostanoligenes were remarkably reduced in ScZ-Ag group (all corrected P<0.001). Meanwhile, 6 SCFAs and 6 neurotransmitters were much lower in ScZ-Ag group (all P<0.05). Finally, a few strongly positive or negative correlations among altered gut microbiota, SCFAs, systemic pro-inflammation, leaky gut, pro-oxidation and aggression severity were detected. Conclusions These results demonstrate that pro-inflammation, pro-oxidation and leaky gut phenotypes relating to enteric dysbacteriosis and microbial SCFAs feature the aggression onset or severity in ScZ individuals.https://doi.org/10.1186/s12888-022-04255-wSchizophreniaAggressionGut microbiotaShort-chain fatty acidNeurotransmitterInflammation |
| spellingShingle | Hongxin Deng Lei He Chong Wang Teng Zhang Hua Guo Hongwei Zhang Yanning Song Bangtao Chen Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression BMC Psychiatry Schizophrenia Aggression Gut microbiota Short-chain fatty acid Neurotransmitter Inflammation |
| title | Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| title_full | Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| title_fullStr | Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| title_full_unstemmed | Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| title_short | Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| title_sort | altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression |
| topic | Schizophrenia Aggression Gut microbiota Short-chain fatty acid Neurotransmitter Inflammation |
| url | https://doi.org/10.1186/s12888-022-04255-w |
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