Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation
Functional constipation (FCon) is a common functional gastrointestinal disorder. A considerable portion of patients with FCon is associated with anxiety/depressive status (FCAD). Previous neuroimaging studies mainly focused on patients with FCon without distinguishing FCAD from FCon patients without...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.628880/full |
| _version_ | 1818437381795086336 |
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| author | Shijun Duan Lei Liu Guanya Li Jia Wang Yang Hu Wenchao Zhang Zongxin Tan Zhenzhen Jia Lei Zhang Karen M. von Deneen Yi Zhang Yongzhan Nie Guangbin Cui |
| author_facet | Shijun Duan Lei Liu Guanya Li Jia Wang Yang Hu Wenchao Zhang Zongxin Tan Zhenzhen Jia Lei Zhang Karen M. von Deneen Yi Zhang Yongzhan Nie Guangbin Cui |
| author_sort | Shijun Duan |
| collection | DOAJ |
| description | Functional constipation (FCon) is a common functional gastrointestinal disorder. A considerable portion of patients with FCon is associated with anxiety/depressive status (FCAD). Previous neuroimaging studies mainly focused on patients with FCon without distinguishing FCAD from FCon patients without anxiety/depressive status (FCNAD). Differences in brain functions between these two subtypes remain unclear. Thus, we employed resting-state functional magnetic resonance imaging (RS-fMRI) and graph theory method to investigate differences in brain network connectivity and topology in 41 FCAD, 42 FCNAD, and 43 age- and gender-matched healthy controls (HCs). FCAD/FCNAD showed significantly lower normalized clustering coefficient and small-world-ness. Both groups showed altered nodal degree/efficiency mainly in the rostral anterior cingulate cortex (rACC), precentral gyrus (PreCen), supplementary motor area (SMA), and thalamus. In the FCAD group, nodal degree in the SMA was negatively correlated with difficulty of defecation, and abdominal pain was positively correlated with nodal degree/efficiency in the rACC, which had a lower within-module nodal degree. The salience network (SN) exhibited higher functional connectivity (FC) with the sensorimotor network (SMN) in FCAD/FCNAD, and FC between these two networks was negatively correlated with anxiety ratings in FCAD group. Additionally, FC of anterior insula (aINS)–rACC was only correlated with constipation symptom (i.e., abdominal pain) in the FCNAD group. In the FCAD group, FCs of dorsomedial prefrontal cortex–rACC, PreCen–aINS showed correlations with both constipation symptom (i.e., difficulty of defecation) and depressive status. These findings indicate the differences in FC of the SN–SMN between FCAD and FCNAD and provide neuroimaging evidence based on brain function, which portrays important clues for improving new treatment strategies. |
| first_indexed | 2024-12-14T17:23:46Z |
| format | Article |
| id | doaj.art-b05b011eba7741b78011a8c1f20ea796 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T17:23:46Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-b05b011eba7741b78011a8c1f20ea7962022-12-21T22:53:17ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-03-011510.3389/fnins.2021.628880628880Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional ConstipationShijun Duan0Lei Liu1Guanya Li2Jia Wang3Yang Hu4Wenchao Zhang5Zongxin Tan6Zhenzhen Jia7Lei Zhang8Karen M. von Deneen9Yi Zhang10Yongzhan Nie11Guangbin Cui12Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaCenter for Brain Imaging, School of Life Sciences and Technology, Xidian University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an, ChinaDepartment of Radiology, Tangdu Hospital, Air Force Medical University, Xi’an, ChinaFunctional constipation (FCon) is a common functional gastrointestinal disorder. A considerable portion of patients with FCon is associated with anxiety/depressive status (FCAD). Previous neuroimaging studies mainly focused on patients with FCon without distinguishing FCAD from FCon patients without anxiety/depressive status (FCNAD). Differences in brain functions between these two subtypes remain unclear. Thus, we employed resting-state functional magnetic resonance imaging (RS-fMRI) and graph theory method to investigate differences in brain network connectivity and topology in 41 FCAD, 42 FCNAD, and 43 age- and gender-matched healthy controls (HCs). FCAD/FCNAD showed significantly lower normalized clustering coefficient and small-world-ness. Both groups showed altered nodal degree/efficiency mainly in the rostral anterior cingulate cortex (rACC), precentral gyrus (PreCen), supplementary motor area (SMA), and thalamus. In the FCAD group, nodal degree in the SMA was negatively correlated with difficulty of defecation, and abdominal pain was positively correlated with nodal degree/efficiency in the rACC, which had a lower within-module nodal degree. The salience network (SN) exhibited higher functional connectivity (FC) with the sensorimotor network (SMN) in FCAD/FCNAD, and FC between these two networks was negatively correlated with anxiety ratings in FCAD group. Additionally, FC of anterior insula (aINS)–rACC was only correlated with constipation symptom (i.e., abdominal pain) in the FCNAD group. In the FCAD group, FCs of dorsomedial prefrontal cortex–rACC, PreCen–aINS showed correlations with both constipation symptom (i.e., difficulty of defecation) and depressive status. These findings indicate the differences in FC of the SN–SMN between FCAD and FCNAD and provide neuroimaging evidence based on brain function, which portrays important clues for improving new treatment strategies.https://www.frontiersin.org/articles/10.3389/fnins.2021.628880/fullfunctional constipationanxiety/depressionresting-state fMRIbrain connectomegraph-theory approachmodularity |
| spellingShingle | Shijun Duan Lei Liu Guanya Li Jia Wang Yang Hu Wenchao Zhang Zongxin Tan Zhenzhen Jia Lei Zhang Karen M. von Deneen Yi Zhang Yongzhan Nie Guangbin Cui Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation Frontiers in Neuroscience functional constipation anxiety/depression resting-state fMRI brain connectome graph-theory approach modularity |
| title | Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation |
| title_full | Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation |
| title_fullStr | Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation |
| title_full_unstemmed | Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation |
| title_short | Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation |
| title_sort | altered functional connectivity within and between salience and sensorimotor networks in patients with functional constipation |
| topic | functional constipation anxiety/depression resting-state fMRI brain connectome graph-theory approach modularity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.628880/full |
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