Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease
Perianal fistula is a very debilitating event and a cause of morbidity in patients with Crohn’s disease (CD). Its malignant transformation is very rare with an incidence of around 0.004–0.7%. Presence of disease in the colon and rectum is the major risk factor for the development of a perianal fistu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2018-08-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/490659 |
| _version_ | 1818960320151945216 |
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| author | Rosario Fornaro Marco Frascio Michela Caratto Elisa Caratto Rita Bianchi Andrea Razzore Giuseppe Caristo Camilla Sticchi Marco Casaccia |
| author_facet | Rosario Fornaro Marco Frascio Michela Caratto Elisa Caratto Rita Bianchi Andrea Razzore Giuseppe Caristo Camilla Sticchi Marco Casaccia |
| author_sort | Rosario Fornaro |
| collection | DOAJ |
| description | Perianal fistula is a very debilitating event and a cause of morbidity in patients with Crohn’s disease (CD). Its malignant transformation is very rare with an incidence of around 0.004–0.7%. Presence of disease in the colon and rectum is the major risk factor for the development of a perianal fistula. In this report we show a case of adenocarcinoma arising from a perianal fistulizing CD. This type of tumor is highly aggressive, difficult to diagnose, and has a rather poor prognosis. The different neoplastic transformations and the different types of tumors that may appear in patients with CD, especially at the colorectal level or at the level of an eventual anastomosis, are to date well documented and described in the literature, while there is a lack of information and of treated cases concerning the occurrence of cancer at the level of a fistula. Due to the rarity of cases, we tried to identify the most frequent and important risk factors: sex, duration of disease, age at diagnosis, and the history of the fistula. |
| first_indexed | 2024-12-20T11:55:39Z |
| format | Article |
| id | doaj.art-b05b3276b75b486f89990ba39f2cb0b3 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-20T11:55:39Z |
| publishDate | 2018-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-b05b3276b75b486f89990ba39f2cb0b32022-12-21T19:41:40ZengKarger PublishersCase Reports in Gastroenterology1662-06312018-08-0112239039510.1159/000490659490659Adenocarcinoma Arising from Perianal Fistulizing Crohn’s DiseaseRosario FornaroMarco FrascioMichela CarattoElisa CarattoRita BianchiAndrea RazzoreGiuseppe CaristoCamilla SticchiMarco CasacciaPerianal fistula is a very debilitating event and a cause of morbidity in patients with Crohn’s disease (CD). Its malignant transformation is very rare with an incidence of around 0.004–0.7%. Presence of disease in the colon and rectum is the major risk factor for the development of a perianal fistula. In this report we show a case of adenocarcinoma arising from a perianal fistulizing CD. This type of tumor is highly aggressive, difficult to diagnose, and has a rather poor prognosis. The different neoplastic transformations and the different types of tumors that may appear in patients with CD, especially at the colorectal level or at the level of an eventual anastomosis, are to date well documented and described in the literature, while there is a lack of information and of treated cases concerning the occurrence of cancer at the level of a fistula. Due to the rarity of cases, we tried to identify the most frequent and important risk factors: sex, duration of disease, age at diagnosis, and the history of the fistula.https://www.karger.com/Article/FullText/490659Crohn’s diseasePerianal fistulaAdenocarcinoma |
| spellingShingle | Rosario Fornaro Marco Frascio Michela Caratto Elisa Caratto Rita Bianchi Andrea Razzore Giuseppe Caristo Camilla Sticchi Marco Casaccia Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease Case Reports in Gastroenterology Crohn’s disease Perianal fistula Adenocarcinoma |
| title | Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease |
| title_full | Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease |
| title_fullStr | Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease |
| title_full_unstemmed | Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease |
| title_short | Adenocarcinoma Arising from Perianal Fistulizing Crohn’s Disease |
| title_sort | adenocarcinoma arising from perianal fistulizing crohn s disease |
| topic | Crohn’s disease Perianal fistula Adenocarcinoma |
| url | https://www.karger.com/Article/FullText/490659 |
| work_keys_str_mv | AT rosariofornaro adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT marcofrascio adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT michelacaratto adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT elisacaratto adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT ritabianchi adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT andrearazzore adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT giuseppecaristo adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT camillasticchi adenocarcinomaarisingfromperianalfistulizingcrohnsdisease AT marcocasaccia adenocarcinomaarisingfromperianalfistulizingcrohnsdisease |