The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
<p>Abstract</p> <p>Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability. Typically, this process is described as being regulated by a coordinated transcriptional hierarchy. However,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-09-01
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| Series: | Skeletal Muscle |
| Subjects: | |
| Online Access: | http://www.skeletalmusclejournal.com/content/1/1/29 |
| _version_ | 1818393290168336384 |
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| author | Knight James DR Kothary Rashmi |
| author_facet | Knight James DR Kothary Rashmi |
| author_sort | Knight James DR |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability. Typically, this process is described as being regulated by a coordinated transcriptional hierarchy. However, like any cellular process, myogenesis is also controlled by members of the protein kinase family, which transmit and execute signals initiated by promyogenic stimuli. In this review, we describe the various kinases involved in mammalian skeletal myogenesis: which step of myogenesis a particular kinase regulates, how it is activated (if known) and what its downstream effects are. We present a scheme of protein kinase activity, similar to that which exists for the myogenic transcription factors, to better clarify the complex signalling that underlies muscle development.</p> |
| first_indexed | 2024-12-14T05:42:57Z |
| format | Article |
| id | doaj.art-b05b440f78174b19b115b6716cbf9131 |
| institution | Directory Open Access Journal |
| issn | 2044-5040 |
| language | English |
| last_indexed | 2024-12-14T05:42:57Z |
| publishDate | 2011-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Skeletal Muscle |
| spelling | doaj.art-b05b440f78174b19b115b6716cbf91312022-12-21T23:14:58ZengBMCSkeletal Muscle2044-50402011-09-01112910.1186/2044-5040-1-29The myogenic kinome: protein kinases critical to mammalian skeletal myogenesisKnight James DRKothary Rashmi<p>Abstract</p> <p>Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability. Typically, this process is described as being regulated by a coordinated transcriptional hierarchy. However, like any cellular process, myogenesis is also controlled by members of the protein kinase family, which transmit and execute signals initiated by promyogenic stimuli. In this review, we describe the various kinases involved in mammalian skeletal myogenesis: which step of myogenesis a particular kinase regulates, how it is activated (if known) and what its downstream effects are. We present a scheme of protein kinase activity, similar to that which exists for the myogenic transcription factors, to better clarify the complex signalling that underlies muscle development.</p>http://www.skeletalmusclejournal.com/content/1/1/29protein kinasesatellite cellmyoblastmyocytemyotubeproliferationdifferentiationfusionhypertrophymyogenesis |
| spellingShingle | Knight James DR Kothary Rashmi The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis Skeletal Muscle protein kinase satellite cell myoblast myocyte myotube proliferation differentiation fusion hypertrophy myogenesis |
| title | The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis |
| title_full | The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis |
| title_fullStr | The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis |
| title_full_unstemmed | The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis |
| title_short | The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis |
| title_sort | myogenic kinome protein kinases critical to mammalian skeletal myogenesis |
| topic | protein kinase satellite cell myoblast myocyte myotube proliferation differentiation fusion hypertrophy myogenesis |
| url | http://www.skeletalmusclejournal.com/content/1/1/29 |
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