The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease
In recent years, the mechanism of cell death has become a hotspot in research on the pathogenesis and treatment of cardiovascular disease (CVD). Different cell death modes, including autophagy, apoptosis, and pyroptosis, are mosaic with each other and collaboratively regulate the process of CVD. Thi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.997469/full |
| _version_ | 1828100153909706752 |
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| author | Lin Cong Lin Cong Yunpeng Bai Yunpeng Bai Zhigang Guo Zhigang Guo |
| author_facet | Lin Cong Lin Cong Yunpeng Bai Yunpeng Bai Zhigang Guo Zhigang Guo |
| author_sort | Lin Cong |
| collection | DOAJ |
| description | In recent years, the mechanism of cell death has become a hotspot in research on the pathogenesis and treatment of cardiovascular disease (CVD). Different cell death modes, including autophagy, apoptosis, and pyroptosis, are mosaic with each other and collaboratively regulate the process of CVD. This review summarizes the interaction and crosstalk of key pathways or proteins which play a critical role in the entire process of CVD and explores the specific mechanisms. Furthermore, this paper assesses the interrelationships among these three cell deaths and reviews how they regulate the pathogenesis of CVD. By understanding how these three cell death modes go together we can learn about the pathogenesis of CVD, which will enable us to identify new targets for preventing, controlling, and treating CVD. It will not only reduce mortality but also improve the quality of life. |
| first_indexed | 2024-04-11T08:24:58Z |
| format | Article |
| id | doaj.art-b05c5bc895654211ab53b2e5ddffe48a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T08:24:58Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b05c5bc895654211ab53b2e5ddffe48a2022-12-22T04:34:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-10-01910.3389/fcvm.2022.997469997469The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular diseaseLin Cong0Lin Cong1Yunpeng Bai2Yunpeng Bai3Zhigang Guo4Zhigang Guo5Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, ChinaDepartment of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, ChinaDepartment of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, ChinaClinical School of Thoracic, Tianjin Medical University, Tianjin, ChinaDepartment of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, ChinaClinical School of Thoracic, Tianjin Medical University, Tianjin, ChinaIn recent years, the mechanism of cell death has become a hotspot in research on the pathogenesis and treatment of cardiovascular disease (CVD). Different cell death modes, including autophagy, apoptosis, and pyroptosis, are mosaic with each other and collaboratively regulate the process of CVD. This review summarizes the interaction and crosstalk of key pathways or proteins which play a critical role in the entire process of CVD and explores the specific mechanisms. Furthermore, this paper assesses the interrelationships among these three cell deaths and reviews how they regulate the pathogenesis of CVD. By understanding how these three cell death modes go together we can learn about the pathogenesis of CVD, which will enable us to identify new targets for preventing, controlling, and treating CVD. It will not only reduce mortality but also improve the quality of life.https://www.frontiersin.org/articles/10.3389/fcvm.2022.997469/fullautophagyapoptosispyroptosiscardiovascular disease (CVD)crosstalk |
| spellingShingle | Lin Cong Lin Cong Yunpeng Bai Yunpeng Bai Zhigang Guo Zhigang Guo The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease Frontiers in Cardiovascular Medicine autophagy apoptosis pyroptosis cardiovascular disease (CVD) crosstalk |
| title | The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease |
| title_full | The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease |
| title_fullStr | The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease |
| title_full_unstemmed | The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease |
| title_short | The crosstalk among autophagy, apoptosis, and pyroptosis in cardiovascular disease |
| title_sort | crosstalk among autophagy apoptosis and pyroptosis in cardiovascular disease |
| topic | autophagy apoptosis pyroptosis cardiovascular disease (CVD) crosstalk |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.997469/full |
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