Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction
Background: The incidence of acute myocardial infarction (AMI) in the younger population has been increasing gradually in recent years. The objective of the present study is to investigate the safety and effectiveness of drug-eluting balloons (DEBs) in young patients with AMI. Methods: All consecuti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/1/29 |
| _version_ | 1827624683152867328 |
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| author | Yi-Xing Yang Kui-Zheng He Jiang-Yuan Li Yuan Fu Chuang Li Xin-Ming Liu Hong-Jiang Wang Mu-Lei Chen Pi-Xiong Su Li Xu Le-Feng Wang |
| author_facet | Yi-Xing Yang Kui-Zheng He Jiang-Yuan Li Yuan Fu Chuang Li Xin-Ming Liu Hong-Jiang Wang Mu-Lei Chen Pi-Xiong Su Li Xu Le-Feng Wang |
| author_sort | Yi-Xing Yang |
| collection | DOAJ |
| description | Background: The incidence of acute myocardial infarction (AMI) in the younger population has been increasing gradually in recent years. The objective of the present study is to investigate the safety and effectiveness of drug-eluting balloons (DEBs) in young patients with AMI. Methods: All consecutive patients with AMI aged ≤ 45 years were retrospectively enrolled. The primary endpoint was a device-oriented composite endpoint (DOCE) of cardiac death, target vessel myocardial infarction (MI), or target lesion revascularization (TLR). The secondary study endpoints included heart failure and major bleeding events. Results: A total of 276 young patients presenting with AMI were finally included. The median follow-up period was 1155 days. Patients treated with DEBs had a trend toward a lower incidence of DOCEs (3.0% vs. 11.0%, <i>p</i> = 0.12) mainly driven by the need for TLR (3.0% vs. 9.1%, <i>p</i> = 0.19) than those treated with DESs. No significant differences between the two groups were detected in the occurrence of cardiac death (0.0% vs. 0.5%, <i>p</i> = 0.69), MI (0.0% vs. 1.4%, <i>p</i> = 0.40), heart failure (0.0% vs. 1.9%, <i>p</i> = 0.39), or major bleeding events (1.5% vs 4.8%, <i>p</i> = 0.30). Multivariate regression analysis showed that DEBs were associated with a trend toward a lower risk of DOCEs (HR 0.13, 95% CI [0.02, 1.05], <i>p</i> = 0.06). Conclusions: The findings of the present study suggested that DEBs might be a potential treatment option in young patients with AMI. A larger scale, randomized, multicenter study is required to investigate the safety and effectiveness of DEBs in this setting. |
| first_indexed | 2024-03-09T12:14:07Z |
| format | Article |
| id | doaj.art-b05cb79a71c0421f920aeafc24da7b8e |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-09T12:14:07Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-b05cb79a71c0421f920aeafc24da7b8e2023-11-30T22:49:20ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-01-011012910.3390/jcdd10010029Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial InfarctionYi-Xing Yang0Kui-Zheng He1Jiang-Yuan Li2Yuan Fu3Chuang Li4Xin-Ming Liu5Hong-Jiang Wang6Mu-Lei Chen7Pi-Xiong Su8Li Xu9Le-Feng Wang10Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, ChinaBackground: The incidence of acute myocardial infarction (AMI) in the younger population has been increasing gradually in recent years. The objective of the present study is to investigate the safety and effectiveness of drug-eluting balloons (DEBs) in young patients with AMI. Methods: All consecutive patients with AMI aged ≤ 45 years were retrospectively enrolled. The primary endpoint was a device-oriented composite endpoint (DOCE) of cardiac death, target vessel myocardial infarction (MI), or target lesion revascularization (TLR). The secondary study endpoints included heart failure and major bleeding events. Results: A total of 276 young patients presenting with AMI were finally included. The median follow-up period was 1155 days. Patients treated with DEBs had a trend toward a lower incidence of DOCEs (3.0% vs. 11.0%, <i>p</i> = 0.12) mainly driven by the need for TLR (3.0% vs. 9.1%, <i>p</i> = 0.19) than those treated with DESs. No significant differences between the two groups were detected in the occurrence of cardiac death (0.0% vs. 0.5%, <i>p</i> = 0.69), MI (0.0% vs. 1.4%, <i>p</i> = 0.40), heart failure (0.0% vs. 1.9%, <i>p</i> = 0.39), or major bleeding events (1.5% vs 4.8%, <i>p</i> = 0.30). Multivariate regression analysis showed that DEBs were associated with a trend toward a lower risk of DOCEs (HR 0.13, 95% CI [0.02, 1.05], <i>p</i> = 0.06). Conclusions: The findings of the present study suggested that DEBs might be a potential treatment option in young patients with AMI. A larger scale, randomized, multicenter study is required to investigate the safety and effectiveness of DEBs in this setting.https://www.mdpi.com/2308-3425/10/1/29drug-eluting balloonacute myocardial infarctionyoung patients |
| spellingShingle | Yi-Xing Yang Kui-Zheng He Jiang-Yuan Li Yuan Fu Chuang Li Xin-Ming Liu Hong-Jiang Wang Mu-Lei Chen Pi-Xiong Su Li Xu Le-Feng Wang Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction Journal of Cardiovascular Development and Disease drug-eluting balloon acute myocardial infarction young patients |
| title | Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction |
| title_full | Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction |
| title_fullStr | Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction |
| title_full_unstemmed | Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction |
| title_short | Comparisons of Drug-Eluting Balloon versus Drug-Eluting Stent in the Treatment of Young Patients with Acute Myocardial Infarction |
| title_sort | comparisons of drug eluting balloon versus drug eluting stent in the treatment of young patients with acute myocardial infarction |
| topic | drug-eluting balloon acute myocardial infarction young patients |
| url | https://www.mdpi.com/2308-3425/10/1/29 |
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