9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation
Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot syn...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Croatian Chemical Society
2015-07-01
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| Series: | Croatica Chemica Acta |
| Online Access: | http://hrcak.srce.hr/file/209501 |
| _version_ | 1828228551454752768 |
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| author | Elma Veljović Selma Špirtović-Halilović Samija Muratović Sunčica Roca Snežana Trifunović Amar Osmanović Davorka Završnik Lidija Valek Žulj |
| author_facet | Elma Veljović Selma Špirtović-Halilović Samija Muratović Sunčica Roca Snežana Trifunović Amar Osmanović Davorka Završnik Lidija Valek Žulj |
| author_sort | Elma Veljović |
| collection | DOAJ |
| description | Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation. |
| first_indexed | 2024-04-12T18:21:57Z |
| format | Article |
| id | doaj.art-b05d3d1036264090887c923bf9950b14 |
| institution | Directory Open Access Journal |
| issn | 0011-1643 1334-417X |
| language | English |
| last_indexed | 2024-04-12T18:21:57Z |
| publishDate | 2015-07-01 |
| publisher | Croatian Chemical Society |
| record_format | Article |
| series | Croatica Chemica Acta |
| spelling | doaj.art-b05d3d1036264090887c923bf9950b142022-12-22T03:21:25ZengCroatian Chemical SocietyCroatica Chemica Acta0011-16431334-417X2015-07-0188212112710.5562/cca25951419839-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency EvaluationElma Veljović0Selma Špirtović-Halilović1Samija Muratović2Sunčica Roca3Snežana Trifunović4Amar Osmanović5Davorka Završnik6Lidija Valek Žulj7Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaNMR Centre, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, CroatiaFaculty of Chemistry, University of Belgrade, Studentski trg 16, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and HerzegovinaDepartment of Electrochemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, CroatiaOxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.http://hrcak.srce.hr/file/209501 |
| spellingShingle | Elma Veljović Selma Špirtović-Halilović Samija Muratović Sunčica Roca Snežana Trifunović Amar Osmanović Davorka Završnik Lidija Valek Žulj 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation Croatica Chemica Acta |
| title | 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation |
| title_full | 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation |
| title_fullStr | 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation |
| title_full_unstemmed | 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation |
| title_short | 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation |
| title_sort | 9 aryl substituted hydroxylated xanthen 3 ones synthesis structure and antioxidant potency evaluation |
| url | http://hrcak.srce.hr/file/209501 |
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