Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease
Purpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral blood smears may offer important information to...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024005589 |
| _version_ | 1797328684653215744 |
|---|---|
| author | Anna Karapetyan Lyudmila Niazyan Ruzanna Shushanyan Tamara Abgaryan Sevan Iritsyan Tehmine Galechyan Knarik Sargsyan Anna Grigoryan |
| author_facet | Anna Karapetyan Lyudmila Niazyan Ruzanna Shushanyan Tamara Abgaryan Sevan Iritsyan Tehmine Galechyan Knarik Sargsyan Anna Grigoryan |
| author_sort | Anna Karapetyan |
| collection | DOAJ |
| description | Purpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral blood smears may offer important information to facilitate the identification. Thus, we evaluated the morphological abnormalities (atypical and immature lymphocytes, lymphocytes with micronuclei, various nuclear abnormalities among erythrocytes) and quantitative changes in peripheral blood cells among 48 individuals with COVID-19 disease. Methods: The present study is a retrospective analysis of 48 individuals, including 24 hospitalized patients diagnosed with COVID-19 disease. The blood smears of all patients were subjected to a hematological examination to identify various morphological abnormalities in white and red blood cells. In addition, a micronucleus test was conducted to assess the incidence of chromosomal damage in lymphocytes. Furthermore, the complete blood count (CBC) was performed to evaluate changes in peripheral blood cells, particularly the differential total leukocyte count, which could indicate the immune response against viral infection in COVID-19 patients. Results: The findings of the hematological study conducted on patients diagnosed with COVID-19 disease revealed neutrophilia, eosinophilia, mild monocytosis, decreased hematocrit level, elevated erythrocyte sedimentation rate (ESR), and immature leukocytes. It was observed that patients who were infected with coronavirus demonstrated mild thrombocytopenia. Furthermore, the micronucleus test indicated the presence of immature cells with micronuclei among lymphocytes and numerous nuclear abnormalities in red blood cells. These results help to shed light on the hematological changes that occur in COVID-19 patients, and could potentially contribute to the development of more effective treatments for the disease. Conclusions: The examination of complete blood counts (CBCs) in conjunction with peripheral blood smears offers a potential means of identifying the impact of SARS-CoV-2 infection on the hematopoietic and immune systems, thereby providing early indications of inflammation. Based on a study, it has been suggested that SARS-CoV-2 may affect red and white blood cells causing morphological alterations thereby establishing a corresponding relationship with disease severity. |
| first_indexed | 2024-03-08T06:55:15Z |
| format | Article |
| id | doaj.art-b05e0d40f973416eb5a69669d377dcc8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:55:15Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b05e0d40f973416eb5a69669d377dcc82024-02-03T06:37:46ZengElsevierHeliyon2405-84402024-01-01102e24527Morphological abnormalities of peripheral blood cells among patients with COVID-19 diseaseAnna Karapetyan0Lyudmila Niazyan1Ruzanna Shushanyan2Tamara Abgaryan3Sevan Iritsyan4Tehmine Galechyan5Knarik Sargsyan6Anna Grigoryan7Department of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, Armenia; Corresponding author.National Centre of Infectious Diseases, Ministry of Health, ArmeniaDepartment of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, ArmeniaDepartment of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, ArmeniaDepartment of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, ArmeniaNational Centre of Infectious Diseases, Ministry of Health, ArmeniaNational Centre of Infectious Diseases, Ministry of Health, ArmeniaDepartment of Human and Animal Physiology, Yerevan State University, 1 Alex Manoogian, RA, Yerevan, 0025, ArmeniaPurpose: The hematological changes in COVID-19 patients continue to receive great attention, especially in the field of public health. To our knowledge, coronavirus disease may be identified based on the severity of illness, and the study of peripheral blood smears may offer important information to facilitate the identification. Thus, we evaluated the morphological abnormalities (atypical and immature lymphocytes, lymphocytes with micronuclei, various nuclear abnormalities among erythrocytes) and quantitative changes in peripheral blood cells among 48 individuals with COVID-19 disease. Methods: The present study is a retrospective analysis of 48 individuals, including 24 hospitalized patients diagnosed with COVID-19 disease. The blood smears of all patients were subjected to a hematological examination to identify various morphological abnormalities in white and red blood cells. In addition, a micronucleus test was conducted to assess the incidence of chromosomal damage in lymphocytes. Furthermore, the complete blood count (CBC) was performed to evaluate changes in peripheral blood cells, particularly the differential total leukocyte count, which could indicate the immune response against viral infection in COVID-19 patients. Results: The findings of the hematological study conducted on patients diagnosed with COVID-19 disease revealed neutrophilia, eosinophilia, mild monocytosis, decreased hematocrit level, elevated erythrocyte sedimentation rate (ESR), and immature leukocytes. It was observed that patients who were infected with coronavirus demonstrated mild thrombocytopenia. Furthermore, the micronucleus test indicated the presence of immature cells with micronuclei among lymphocytes and numerous nuclear abnormalities in red blood cells. These results help to shed light on the hematological changes that occur in COVID-19 patients, and could potentially contribute to the development of more effective treatments for the disease. Conclusions: The examination of complete blood counts (CBCs) in conjunction with peripheral blood smears offers a potential means of identifying the impact of SARS-CoV-2 infection on the hematopoietic and immune systems, thereby providing early indications of inflammation. Based on a study, it has been suggested that SARS-CoV-2 may affect red and white blood cells causing morphological alterations thereby establishing a corresponding relationship with disease severity.http://www.sciencedirect.com/science/article/pii/S2405844024005589CoronavirusHematological abnormalitiesSARS-CoV-2HematopoesisLymphocytes |
| spellingShingle | Anna Karapetyan Lyudmila Niazyan Ruzanna Shushanyan Tamara Abgaryan Sevan Iritsyan Tehmine Galechyan Knarik Sargsyan Anna Grigoryan Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease Heliyon Coronavirus Hematological abnormalities SARS-CoV-2 Hematopoesis Lymphocytes |
| title | Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease |
| title_full | Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease |
| title_fullStr | Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease |
| title_full_unstemmed | Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease |
| title_short | Morphological abnormalities of peripheral blood cells among patients with COVID-19 disease |
| title_sort | morphological abnormalities of peripheral blood cells among patients with covid 19 disease |
| topic | Coronavirus Hematological abnormalities SARS-CoV-2 Hematopoesis Lymphocytes |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024005589 |
| work_keys_str_mv | AT annakarapetyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT lyudmilaniazyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT ruzannashushanyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT tamaraabgaryan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT sevaniritsyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT tehminegalechyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT knariksargsyan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease AT annagrigoryan morphologicalabnormalitiesofperipheralbloodcellsamongpatientswithcovid19disease |